Imaging Assessment of Prostate Cancer Extra-prostatic Extension: From Histology to Controversies

Prostate cancer (PCa) is the most common non-skin malignancy among men and the fourth leading cause of cancer-related deaths globally. Accurate staging of PCa, particularly the assessment of extra-prostatic extension (EPE), is critical for prognosis and treatment planning. EPE, typically evaluated using magnetic resonance imaging (MRI), is associated with higher risks of positive surgical margins, biochemical recurrence, metastasis, and reduced overall survival. Despite the widespread use of MRI, there is no consensus on diagnosing EPE via imaging. There are 2 main scores assessing EPE by MRI: the European Society of Urogenital Radiology score and an MRI-based EPE grading system from an American group. While both are widely recognized, their differences can lead to varying interpretations in specific cases. This paper clarifies the anatomical considerations in diagnosing locally advanced PCa, explores EPE’s impact on treatment and prognosis, and evaluates the relevance of MRI findings according to different criteria. Accurate EPE diagnosis remains challenging due to MRI limitations and inconsistencies in interpretation. Understanding these variations is crucial for optimal patient management.