Christian Schmidkonz, Torsten Kuwert, Theresa Ida Götz, Andreas Ramming, Armin Atzinger
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引用次数: 0
摘要
使用正电子发射断层扫描/计算机断层扫描（PET/CT）的混合成像技术为与炎症疾病相关的分子过程成像带来了革命性的变化。正电子发射断层扫描/计算机断层扫描（PET/CT）可视化代谢活动和蛋白质表达，并提供全面的全身评估。它有可能在发现炎症性关节疾病的结构变化之前揭示炎症。FAP 是一种 II 型跨膜糖蛋白，不仅在肿瘤基质中过度表达，而且在某些免疫介导疾病的纤维化过程中也过度表达。最近推出的成纤维细胞活化蛋白抑制剂（FAPI）由正电子发射器标记，因此适用于 PET/CT，可用于研究 FAP 在体内的表达。本综述将重点介绍 FAPI-PET/CT 在炎症性关节疾病诊断和治疗反应评估中的应用。
Recent advances in nuclear medicine and their role in inflammatory arthritis: focus on the emerging role of FAPI PET/CT.
Imaging molecular processes associated with inflammatory disease has been revolutionized by hybrid imaging using positron emission tomography/computed tomography (PET/CT). PET/CT visualizes metabolic activity as well as protein expression and provides a comprehensive whole-body evaluation. It has the potential to reveal inflammation prior to detection of structural changes in inflammatory joint diseases. FAP is a type II transmembrane glycoprotein overexpressed not only in the stroma of tumors but also in the fibrotic processes of certain immune-mediated disorders. The recent introduction of fibroblast activation protein inhibitors (FAPI) labeled by positron emitters and thus suitable for PET/CT allows to investigate FAP expression in vivo. This review will focus on the use of FAPI-PET/CT for the diagnosis and evaluation of treatment response in inflammatory joint diseases.
期刊介绍：
Skeletal Radiology provides a forum for the dissemination of current knowledge and information dealing with disorders of the musculoskeletal system including the spine. While emphasizing the radiological aspects of the many varied skeletal abnormalities, the journal also adopts an interdisciplinary approach, reflecting the membership of the International Skeletal Society. Thus, the anatomical, pathological, physiological, clinical, metabolic and epidemiological aspects of the many entities affecting the skeleton receive appropriate consideration.
This is the Journal of the International Skeletal Society and the Official Journal of the Society of Skeletal Radiology and the Australasian Musculoskelelal Imaging Group.
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