治疗白血病的骨髓祖细胞。

IF 23.5 1区医学 Q1 ONCOLOGY

Nature cancer Pub Date : 2024-11-25 DOI:10.1038/s43018-024-00864-4

Sarah Elitzur, Shai Izraeli

引用次数: 0

摘要

T细胞急性淋巴细胞白血病（T- all）的复发构成了一个挑战。骨髓祖细胞样细胞亚克隆群体存在于所有T-ALL遗传或免疫表型亚型中，现在被证明具有化疗耐药和不良预后，并且是抗凋亡药物的靶标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Bone marrow progenitor-like cells against leukemia cure

查看原文本刊更多论文

Bone marrow progenitor-like cells against leukemia cure

Relapse in T cell acute lymphoblastic leukemia (T-ALL) constitutes a challenge. A subclonal population of bone marrow progenitor-like cells present in all T-ALL genetic or immunophenotypic subtypes is now shown to confer chemoresistance and poor prognosis, and to be targetable with anti-apoptotic agents.

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来源期刊

Nature cancer Medicine-Oncology

CiteScore

31.10

自引率

1.80%

发文量

129

期刊介绍： Cancer is a devastating disease responsible for millions of deaths worldwide. However, many of these deaths could be prevented with improved prevention and treatment strategies. To achieve this, it is crucial to focus on accurate diagnosis, effective treatment methods, and understanding the socioeconomic factors that influence cancer rates. Nature Cancer aims to serve as a unique platform for sharing the latest advancements in cancer research across various scientific fields, encompassing life sciences, physical sciences, applied sciences, and social sciences. The journal is particularly interested in fundamental research that enhances our understanding of tumor development and progression, as well as research that translates this knowledge into clinical applications through innovative diagnostic and therapeutic approaches. Additionally, Nature Cancer welcomes clinical studies that inform cancer diagnosis, treatment, and prevention, along with contributions exploring the societal impact of cancer on a global scale. In addition to publishing original research, Nature Cancer will feature Comments, Reviews, News & Views, Features, and Correspondence that hold significant value for the diverse field of cancer research.