特发性眼眶肌炎的复发模式。

IF 2.4 3区 医学 Q2 OPHTHALMOLOGY
Terence Ang, Jessica Y Tong, Sandy Patel, Thomas G Hardy, Alan McNab, Dinesh Selva
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引用次数: 0

摘要

目的:描述特发性眼眶肌炎(IOM)疾病复发的模式:方法:对特发性眼眶肌炎患者进行多中心回顾性纵向研究。同时还分析了连续影像学资料。不包括临床记录不完整的患者和特殊眼眶肌炎(如甲状腺相关眼病)患者:33 名患者(女性:18 名,平均年龄:40.8 ± 16.8 岁)于 2001 年至 2023 年间发病。12名患者(36.4%)疾病复发。复发和未复发患者的年龄或性别偏好没有差异(P = 0.107 和 0.469)。多发EOM受累、单侧疾病、前部肌腱疏松或泪腺受累的患者与复发之间没有关联(P分别为0.328、1.0、0.630和0.686)。8例(66.7%)患者复发时仅累及单个EOM,10例(83.3%)患者复发时累及的EOM与初次发病时不同。7名患者(58.3%)的对侧眼眶同时受累,1名患者(8.3%)的双侧眼眶同时受累。年龄、性别、最初出现单个EOM或泪腺受累的患者与出现对侧眼眶肌炎(即同时出现双侧疾病)之间没有关联(P=0.777、0.491、0.109和0.236)。在单次急性发作的患者中,有两名(9.5%)患者出现眼部残留症状,而复发患者有四名(33.3%)(P = 0.159):本研究总结了IOM的复发模式。复发与年龄、性别、多发性EOM受累、双侧疾病、肌腱保护或泪腺受累无关。在不同样本的患者中均可观察到复发情况,复发患者可能经常患上对侧疾病或累及不同的EOM(即 "移行性 "疾病)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Patterns of recurrence in idiopathic orbital myositis.

Purpose: To characterise patterns of disease recurrence in idiopathic orbital myositis (IOM).

Methods: Multi-centre retrospective longitudinal study of IOM patients. Serial imaging was also analysed. Patients with incomplete clinical records and specific orbital myositis (e.g. thyroid-associated ophthalmopathy) were excluded.

Results: Thirty-three patients (Female: 18, mean age: 40.8 ± 16.8-years-old) presenting between 2001 and 2023. Twelve (36.4%) patients had disease recurrence. There was no difference between age or sex predilection of patients with and without recurrence (P = 0.107 and 0.469, respectively). There was no association between patients presenting with multiple EOM involvement, unilateral disease, anterior tendon sparing or lacrimal gland involvement with recurrence (P = 0.328, 1.0, 0.630 and 0.686, respectively). Recurrence with single EOM involvement occurred in eight (66.7%) patients, and ten (83.3%) patients had recurrence involving different EOM(s) than on initial presentation. Seven (58.3%) patients had metachronous contralateral orbital involvement and one (8.3%) had simultaneous bilateral involvement. There was no association between age, sex, patients presenting initially with single EOM or lacrimal gland involvement with the development of contralateral orbital myositis (i.e. metachronous bilateral disease) (P = 0.777, 0.491, 0.109, and 0.236, respectively). Of the patients with a single acute episode, two (9.5%) patients experienced residual ocular symptoms, compared to four (33.3%) patients with recurrent disease (P = 0.159).

Conclusion: This study summarises the patterns of recurrence in IOM. Recurrence was not associated with age, sex, multiple EOM involvement, bilateral disease, tendon-sparing or lacrimal gland involvement. Recurrence was observed in a heterogenous sample of patients and may frequently develop contralateral disease or involve different EOMs (i.e. 'migratory' disease).

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来源期刊
CiteScore
5.40
自引率
7.40%
发文量
398
审稿时长
3 months
期刊介绍: Graefe''s Archive for Clinical and Experimental Ophthalmology is a distinguished international journal that presents original clinical reports and clini-cally relevant experimental studies. Founded in 1854 by Albrecht von Graefe to serve as a source of useful clinical information and a stimulus for discussion, the journal has published articles by leading ophthalmologists and vision research scientists for more than a century. With peer review by an international Editorial Board and prompt English-language publication, Graefe''s Archive provides rapid dissemination of clinical and clinically related experimental information.
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