Raquel Galván , P. Fernandez-Riejos , C. Sánchez Mora , M. Salgueira Lazo , W. Aguilera Morales , A. Monzón , M. Jiménez Barragán , C. Rodriguez-Chacón , I. Almazo Guerrero , A. León Justel
{"title":"通过警报系统及早发现急性肾损伤可改善住院病人的预后。","authors":"Raquel Galván , P. Fernandez-Riejos , C. Sánchez Mora , M. Salgueira Lazo , W. Aguilera Morales , A. Monzón , M. Jiménez Barragán , C. Rodriguez-Chacón , I. Almazo Guerrero , A. León Justel","doi":"10.1016/j.cca.2024.120061","DOIUrl":null,"url":null,"abstract":"<div><h3>Background and Aims</h3><div>Acute kidney injury (AKI) acquired in hospital settings has emerged as a significant public health issue. It is linked to prolonged hospital stays, increased healthcare costs, heightened risk of developing chronic kidney disease, mortality, and the need for ongoing post-hospitalization care. Our hypothesis suggests that timely recognition of AKI, identification of its underlying causes, and expert management by specialists could lead to improved prognoses for hospitalized patients.</div></div><div><h3>Materials and methods</h3><div>We have devised an electronic-alert system that incorporates an action and follow-up plan overseen by a multidisciplinary team of hospital professionals. We compared the prognosis of patients measured in terms of length of hospital stay, in-hospital mortality and improvement of renal function at different points.</div></div><div><h3>Results</h3><div>Almost 80 % of patients in the Intervention group had a significant decrease in serum creatinine 48 h after the alert. The length of hospital stay was longer in the Non-Intervention group than in the Intervention group: 12 (8 – 20) vs 10 (6 – 15) days (p = 0.002), as was mortality during hospitalization: 34 % of cases vs 19.9 % (p = 0.002). The median survival of the Non-Intervention group was estimated at 20 (14 – 26) days, while that of the Intervention group was estimated at 33 (20 – 45) days.</div></div><div><h3>Conclusions</h3><div>Our study highlights the importance of closely monitoring at-risk patients for AKI during and after hospitalization. Prompt risk assessment and interventions by healthcare professionals, including clinical laboratory involvement, could improve AKI prognosis.</div></div>","PeriodicalId":10205,"journal":{"name":"Clinica Chimica Acta","volume":"566 ","pages":"Article 120061"},"PeriodicalIF":3.2000,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Early detection of acute kidney injury through an alert system improves outcomes in hospitalized patients\",\"authors\":\"Raquel Galván , P. Fernandez-Riejos , C. Sánchez Mora , M. Salgueira Lazo , W. Aguilera Morales , A. Monzón , M. Jiménez Barragán , C. Rodriguez-Chacón , I. Almazo Guerrero , A. León Justel\",\"doi\":\"10.1016/j.cca.2024.120061\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background and Aims</h3><div>Acute kidney injury (AKI) acquired in hospital settings has emerged as a significant public health issue. It is linked to prolonged hospital stays, increased healthcare costs, heightened risk of developing chronic kidney disease, mortality, and the need for ongoing post-hospitalization care. Our hypothesis suggests that timely recognition of AKI, identification of its underlying causes, and expert management by specialists could lead to improved prognoses for hospitalized patients.</div></div><div><h3>Materials and methods</h3><div>We have devised an electronic-alert system that incorporates an action and follow-up plan overseen by a multidisciplinary team of hospital professionals. We compared the prognosis of patients measured in terms of length of hospital stay, in-hospital mortality and improvement of renal function at different points.</div></div><div><h3>Results</h3><div>Almost 80 % of patients in the Intervention group had a significant decrease in serum creatinine 48 h after the alert. The length of hospital stay was longer in the Non-Intervention group than in the Intervention group: 12 (8 – 20) vs 10 (6 – 15) days (p = 0.002), as was mortality during hospitalization: 34 % of cases vs 19.9 % (p = 0.002). The median survival of the Non-Intervention group was estimated at 20 (14 – 26) days, while that of the Intervention group was estimated at 33 (20 – 45) days.</div></div><div><h3>Conclusions</h3><div>Our study highlights the importance of closely monitoring at-risk patients for AKI during and after hospitalization. Prompt risk assessment and interventions by healthcare professionals, including clinical laboratory involvement, could improve AKI prognosis.</div></div>\",\"PeriodicalId\":10205,\"journal\":{\"name\":\"Clinica Chimica Acta\",\"volume\":\"566 \",\"pages\":\"Article 120061\"},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2024-11-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinica Chimica Acta\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0009898124023143\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICAL LABORATORY TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinica Chimica Acta","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0009898124023143","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICAL LABORATORY TECHNOLOGY","Score":null,"Total":0}
Early detection of acute kidney injury through an alert system improves outcomes in hospitalized patients
Background and Aims
Acute kidney injury (AKI) acquired in hospital settings has emerged as a significant public health issue. It is linked to prolonged hospital stays, increased healthcare costs, heightened risk of developing chronic kidney disease, mortality, and the need for ongoing post-hospitalization care. Our hypothesis suggests that timely recognition of AKI, identification of its underlying causes, and expert management by specialists could lead to improved prognoses for hospitalized patients.
Materials and methods
We have devised an electronic-alert system that incorporates an action and follow-up plan overseen by a multidisciplinary team of hospital professionals. We compared the prognosis of patients measured in terms of length of hospital stay, in-hospital mortality and improvement of renal function at different points.
Results
Almost 80 % of patients in the Intervention group had a significant decrease in serum creatinine 48 h after the alert. The length of hospital stay was longer in the Non-Intervention group than in the Intervention group: 12 (8 – 20) vs 10 (6 – 15) days (p = 0.002), as was mortality during hospitalization: 34 % of cases vs 19.9 % (p = 0.002). The median survival of the Non-Intervention group was estimated at 20 (14 – 26) days, while that of the Intervention group was estimated at 33 (20 – 45) days.
Conclusions
Our study highlights the importance of closely monitoring at-risk patients for AKI during and after hospitalization. Prompt risk assessment and interventions by healthcare professionals, including clinical laboratory involvement, could improve AKI prognosis.
期刊介绍:
The Official Journal of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC)
Clinica Chimica Acta is a high-quality journal which publishes original Research Communications in the field of clinical chemistry and laboratory medicine, defined as the diagnostic application of chemistry, biochemistry, immunochemistry, biochemical aspects of hematology, toxicology, and molecular biology to the study of human disease in body fluids and cells.
The objective of the journal is to publish novel information leading to a better understanding of biological mechanisms of human diseases, their prevention, diagnosis, and patient management. Reports of an applied clinical character are also welcome. Papers concerned with normal metabolic processes or with constituents of normal cells or body fluids, such as reports of experimental or clinical studies in animals, are only considered when they are clearly and directly relevant to human disease. Evaluation of commercial products have a low priority for publication, unless they are novel or represent a technological breakthrough. Studies dealing with effects of drugs and natural products and studies dealing with the redox status in various diseases are not within the journal''s scope. Development and evaluation of novel analytical methodologies where applicable to diagnostic clinical chemistry and laboratory medicine, including point-of-care testing, and topics on laboratory management and informatics will also be considered. Studies focused on emerging diagnostic technologies and (big) data analysis procedures including digitalization, mobile Health, and artificial Intelligence applied to Laboratory Medicine are also of interest.