Charlotte Gerhard, Isabelle Masseau, Aida Vientos-Plotts, Gregory F Petroski, Carol Reinero
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引用次数: 0
摘要
目的：使用自动软件分析记录支气管扩张症（BM）犬和无 BM 犬（NoBM）吸气和呼气屏气 CT 肺实质衰减的客观指标。衡量标准包括平均肺衰减、-856 HU 的低衰减区域百分比、-700 HU 的高衰减区域百分比以及-600 和 -250 HU 之间的衰减区域百分比：动物：客户饲养的患有骨髓瘤（n = 123）和无骨髓瘤（20）的狗：这项回顾性研究使用 3D Slicer 软件（布里格姆妇女医院）评估肺部 CT 衰减。分析采用斯皮尔曼相关性和带贝塔回归的双向方差分析：比较吸气期和呼气期的差异，BM 狗和 NoBM 狗的平均肺衰减显著增加（P = .001），-856 HU 处的低衰减面积百分比显著减少（P = .016），-700 HU 处的高衰减面积百分比和-600 到 -250 HU 之间的衰减面积百分比显著增加（分别为 P < .001 和 P < .0001）：结论：与 NoBM 犬相比，BM 犬吸气和呼气时的肺衰减差异更大，这证明节段性和亚节段性气道塌陷的下游实质通气功能受损：定量图像分析有望客观评估 BM 的变化。
Objective assessment of computed tomographic pulmonary attenuation of inspiratory and expiratory series in dogs with and without bronchomalacia.
Objective: To document objective metrics of attenuation of the pulmonary parenchyma on inspiratory and expiratory breath-hold CT in dogs with bronchomalacia (BM) and dogs without BM (NoBM) using automated software analysis. Metrics included mean lung attenuation, percent low-attenuation area at -856 HU, percent high-attenuation area at -700 HU, and percent attenuation area between -600 and -250 HU.
Animals: Client-owned dogs with BM (n = 123) and NoBM (20).
Methods: This retrospective study utilized 3D Slicer software (Brigham and Women's Hospital) to assess pulmonary CT attenuation. Analysis used Spearman correlation and 2-way ANOVA with beta regression.
Results: Comparing the difference between inspiratory and expiratory phases, there was a significantly greater increase in mean lung attenuation (P = .001), a significant reduction in percent low-attenuation area at -856 HU (P = .016), and a significant increase in percent high-attenuation area at -700 HU and percent attenuation area between -600 and -250 HU (P < .001 and P < .0001, respectively) in BM versus NoBM dogs.
Conclusions: The higher inspiratory and expiratory difference in lung attenuation in BM compared to NoBM dogs supports the presence of impaired parenchymal aeration downstream of segmental and subsegmental airway collapse.
Clinical relevance: Quantitative image analysis holds promise for objectively evaluating changes with BM.
期刊介绍：
The American Journal of Veterinary Research supports the collaborative exchange of information between researchers and clinicians by publishing novel research findings that bridge the gulf between basic research and clinical practice or that help to translate laboratory research and preclinical studies to the development of clinical trials and clinical practice. The journal welcomes submission of high-quality original studies and review articles in a wide range of scientific fields, including anatomy, anesthesiology, animal welfare, behavior, epidemiology, genetics, heredity, infectious disease, molecular biology, oncology, pharmacology, pathogenic mechanisms, physiology, surgery, theriogenology, toxicology, and vaccinology. Species of interest include production animals, companion animals, equids, exotic animals, birds, reptiles, and wild and marine animals. Reports of laboratory animal studies and studies involving the use of animals as experimental models of human diseases are considered only when the study results are of demonstrable benefit to the species used in the research or to another species of veterinary interest. Other fields of interest or animals species are not necessarily excluded from consideration, but such reports must focus on novel research findings. Submitted papers must make an original and substantial contribution to the veterinary medicine knowledge base; preliminary studies are not appropriate.
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