COVID-19大流行导致的社会隔离对阿尔茨海默病患者认知功能障碍的影响：多奈哌齐贴剂和多奈哌齐片剂双盲非劣效性研究子分析》。

IF 1.8 4区医学 Q3 CLINICAL NEUROLOGY

Alzheimer Disease & Associated Disorders Pub Date : 2024-10-01 Epub Date: 2024-11-13 DOI:10.1097/WAD.0000000000000648

Yu Nakamura, Takumi Omori, Kenichi Nishiyama, Ichiro Ishikawa, Hiroshi Aoki, Naoki Nagakura

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引用次数: 0

摘要

背景：以前的研究考察了COVID-19大流行对老年人的社会限制的影响，或比较了限制前后对阿尔茨海默病相关痴呆症（ADRD）患者的差异。在此，我们通过对比对照组，评估了限制对患者认知功能的影响：我们通过对多奈哌齐 27.5 毫克贴片和盐酸多奈哌齐 5 毫克片剂（JapicCTI-194582）的双盲、非劣效性研究进行事后分组分析，使用阿尔茨海默病评估量表（日文版）认知分量表（ADAS-JCOG）检查了对轻度至中度 ADRD 患者认知功能的影响。在证明两种治疗方法的非劣效性后，我们采用了合并数据进行分析：按方案分组的分析亚群是均衡的（分别为 126 人和 135 人）。两组患者的人口统计学特征相似。各组之间的 ADAS-JCOG 评分[最小二乘均值（95%CI）]差异为 0.388（-0.377 至 1.152，无统计学意义）：结论：社会隔离会影响 ADRD 患者的认知功能，今后应考虑这方面的知识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Effect of Social Isolation Due to the COVID-19 Pandemic on Cognitive Dysfunction of Patients With Alzheimer Disease: Subanalysis of Double-blinded Noninferiority Study of Donepezil Patches and Donepezil Tablets.

Background: Previous studies were examined effects of social restriction by COVID-19 pandemic on elderly peoples or compared difference of before/after restrictions on patients with Alzheimer disease-related dementia (ADRD). Here, we assessed the effects of restrictions on the cognitive function of the patients by comparing control group.

Methods: We examined the impact on cognitive function using the Alzheimer Disease Assessment Scale (Japanese version) cognitive subscale (ADAS-JCOG), in patients with mild to moderate ADRD by a post hoc subgroup analysis of double-blinded, noninferiority study of donepezil 27.5 mg patches and donepezil hydrochloride 5 mg tablets (JapicCTI-194582). After demonstrating the noninferiority of both treatments, we used combined data for this analysis.

Results: The analyzed subpopulation of the per-protocol set groups was balanced (n=126 and 135, respectively). Patient demographics were similar between subgroups. The difference of ADAS-JCOG scores [least-squares mean (95%CI)] between the groups was 0.388 (-0.377 to 1.152, not statistically significant).

Conclusion: Social isolation affects cognitive function on ADRD and this knowledge should be considered in future.

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来源期刊

Alzheimer Disease & Associated Disorders 医学-病理学

CiteScore

3.10

自引率

4.80%

发文量

期刊介绍： Alzheimer Disease & Associated Disorders is a peer-reviewed, multidisciplinary journal directed to an audience of clinicians and researchers, with primary emphasis on Alzheimer disease and associated disorders. The journal publishes original articles emphasizing research in humans including epidemiologic studies, clinical trials and experimental studies, studies of diagnosis and biomarkers, as well as research on the health of persons with dementia and their caregivers. The scientific portion of the journal is augmented by reviews of the current literature, concepts, conjectures, and hypotheses in dementia, brief reports, and letters to the editor.