Guo-Dong Shen, Zhi-Rong Zhao, Kun Bi, Yi Man, Jun-Tong Liu, Xian-Qiang Huang, Xin Lv
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Room temperature natural light promoted DMSO/O2-catalyzed N-acylation reaction of imidazoles/triazoles with cyclopropenones.
An unprecedented natural light promoted DMSO/O2-catalyzed N-acylation reaction of imidazoles/triazoles with cyclopropenones at room temperature under metal-free conditions has been developed. The remarkable advantages of this strategy include atomic economy and environmentally benign conditions (such as natural light promotion, DMSO/O2-catalysis, room temperature, and DMC as solvent), stereospecific (E)-olefins synthesis (N-acyl imidazoles and triazoles), wide functional group tolerance and high reaction yields. Furthermore, the typical products (1c and 1e) display good photocurrent and electrochemical property and are potentially applicable in biosensor materials fields.
期刊介绍:
Molecular Diversity is a new publication forum for the rapid publication of refereed papers dedicated to describing the development, application and theory of molecular diversity and combinatorial chemistry in basic and applied research and drug discovery. The journal publishes both short and full papers, perspectives, news and reviews dealing with all aspects of the generation of molecular diversity, application of diversity for screening against alternative targets of all types (biological, biophysical, technological), analysis of results obtained and their application in various scientific disciplines/approaches including:
combinatorial chemistry and parallel synthesis;
small molecule libraries;
microwave synthesis;
flow synthesis;
fluorous synthesis;
diversity oriented synthesis (DOS);
nanoreactors;
click chemistry;
multiplex technologies;
fragment- and ligand-based design;
structure/function/SAR;
computational chemistry and molecular design;
chemoinformatics;
screening techniques and screening interfaces;
analytical and purification methods;
robotics, automation and miniaturization;
targeted libraries;
display libraries;
peptides and peptoids;
proteins;
oligonucleotides;
carbohydrates;
natural diversity;
new methods of library formulation and deconvolution;
directed evolution, origin of life and recombination;
search techniques, landscapes, random chemistry and more;