通过巨噬细胞介导的免疫调节治疗生物膜感染并促进感染性骨缺损骨整合的多功能含钴植入物

IF 14.3 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Nongyang Yan, Hao Zhou, Penghe Jin, Tengfei Li, Qi Liu, Hao Ning, Zhixin Ma, Linfei Feng, Tao Jin, Youwen Deng, Zhengwei Wu
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引用次数: 0

摘要

治疗骨感染和确保骨恢复是现代骨科面临的主要全球性问题之一。长期使用抗生素可能会增加抗菌药耐药性的风险,而生物膜引起的炎症会阻碍组织愈合,这使得骨感染治疗更具挑战性。最佳治疗策略是将改变免疫反应以促进骨生成与有效清除细菌感染相结合,而无需长期使用抗生素。一步式等离子浸入离子注入法被用于制造含钴的钛合金植入物。实验结果表明,含钴钛合金植入体有效地破坏了生物膜的形成,并将耐甲氧西林金黄色葡萄球菌的附着率降低了 80% 以上,从而提高了抗菌活性。此外,这种植入物还具有卓越的抗炎和骨结合特性。RNA 测序分析揭示了 Co2+ 在调节巨噬细胞向抗炎 M2 表型极化方面的潜在机制,这对于创造有利于骨愈合的免疫环境至关重要。同时,这些植入物在抑制破骨细胞活性的同时促进了成骨分化,进一步支持了骨修复。总之,在不使用外源性重组蛋白或抗生素的情况下,这些植入物能有效消除感染并加快骨修复,为复杂骨骼疾病提供了一种新型治疗策略,具有良好的临床前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Multifunctional Cobalt-Containing Implant for Treating Biofilm Infections and Promoting Osteointegration in Infected Bone Defects Through Macrophage-Mediated Immunomodulation.

Treating bone infections and ensuring bone recovery is one of the major global problems facing modern orthopedics. Prolonged antibiotic use may increase the risk of antimicrobial resistance, and inflammation caused by biofilms can obstruct tissue healing, making bone infection treatment even more challenging. The optimal treatment strategy combines immune response modification to promote osteogenesis with effective bacterial infection removal that does not require long-term antibiotic use. A one-step plasma immersion ion implantation approach is used to create titanium alloy implants incorporating cobalt. According to experimental findings, cobalt-containing titanium implants exhibit improved antibacterial activity by efficiently disrupting biofilm formations and reducing Methicillin-resistant Staphylococcus aureus adherence by over 80%. Additionally, the implants exhibit superior anti-inflammatory and osseointegration properties. RNA sequencing analysis reveals the potential mechanism of Co2+ in regulating the polarization of macrophages toward the anti-inflammatory M2 phenotype, which is crucial for creating an immune environment conducive to bone healing. Concurrently, these implants promote osteogenic differentiation while suppressing osteoclast activity, further supporting bone repair. Overall, without exogenous recombinant proteins or antibiotics, the implants effectively eradicate infections and expedite bone repair, offering a novel therapeutic strategy for complex skeletal diseases with clinical promise.

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来源期刊
Advanced Science
Advanced Science CHEMISTRY, MULTIDISCIPLINARYNANOSCIENCE &-NANOSCIENCE & NANOTECHNOLOGY
CiteScore
18.90
自引率
2.60%
发文量
1602
审稿时长
1.9 months
期刊介绍: Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.
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