TFA 促进喹喔啉-2-酮衍生物与富电子芳香化合物的（杂）芳基化/羟基化反应。

IF 2.7 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2024-11-06 DOI:10.1039/d4ob00882k

Ramanna Jatoth , Kishan Gugulothu , Nidhi Ravi , Ranamalla Gayathri , Shravani Parehosahalli Chandrakumar , K. Shiva Kumar

引用次数: 0

摘要

报告了一种无金属、无溶剂、一锅制和 TFA 促进法，用于构建杂/芳基取代的喹喔啉-2-酮、吡嗪-2(1H)-酮和嘧啶-4(3H)-酮。该方法涉及氮杂环的氯衍生物与富电子的炔/异炔反应，然后进行羟基化反应。该方法易于使用，能以良好的产率获得（杂）芳基取代的 N-杂环。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

TFA-promoted (hetero)arylation/hydroxylation of quinoxaline-2-one derivatives with electron-rich aromatic compounds†

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TFA-promoted (hetero)arylation/hydroxylation of quinoxaline-2-one derivatives with electron-rich aromatic compounds†

A metal- and solvent-free, one-pot and TFA-promoted method for the construction of hetero/aryl-substituted quinoxalin-2-ones, pyrazin-2(1H)-ones, and pyrimidin-4(3H)-ones is reported. This method involves the reaction of chloro-derivatives of nitrogen heterocycles with electron-rich arenes/heteroarenes, followed by hydroxylation. This protocol is easy to use, providing access to (hetero)aryl-substituted N-heterocycles in good yields.

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.