牙科硬组织修复材料的进步与临床转化的挑战

IF 6.8 2区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY
Bowen Hu  (, ), Yanyun Pang  (, ), Xiaoxue Yang  (, ), Kun Xuan  (, ), Xu Zhang  (, ), Peng Yang  (, )
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引用次数: 0

摘要

牙齿硬组织,主要是牙釉质和牙本质,具有切割、咀嚼、说话和保持面部美观等基本功能,主要由排列整齐的羟基磷灰石(HAp)纳米晶体与蛋白质基质交错组成。这些组织具有卓越的机械和美学特性。然而,一旦受损,其自我修复能力就极为有限,并经常伴有牙本质过敏症(DH)。目前,虽然使用合成材料和再矿化技术进行的牙科修复在临床上取得了进展,但这些方法仍然存在局限性,影响了其在临床上的广泛应用。因此,了解牙体硬组织的形成机制,开发能模拟天然牙并满足临床需求的高性能修复技术至关重要。本综述将重点介绍釉质再生和牙本质脱敏的当前策略和研究进展,以及临床转化所面临的挑战。我们强调,科学研究应以临床需求为出发点,这些研究通过转化最终服务于临床,形成相互促进的良性循环。本综述旨在为牙科硬组织的预防和治疗提供新的视角,促进修复材料和技术的创新,为患者带来更好的临床转化产品和服务。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Advancements in dental hard tissue restorative materials and challenge of clinical translation

Dental hard tissues, primarily enamel and dentin, serving essential functions such as cutting, chewing, speaking, and maintaining facial aesthetics, mainly composed well-aligned hydroxyapatite (HAp) nanocrystals interlaced with a protein matrix. These tissues exhibit remarkable mechanical and aesthetic behaviors. However, once damaged, its ability to self-repair is extremely limited, often accompanied by dentin hypersensitivity (DH). Currently, although dental restorations using synthetic materials and remineralization techniques have made clinical progress, these methods still have limitations that affect their widespread use in clinical applications. Therefore, understanding the formation mechanisms of dental hard tissues and developing high-performance restorative technologies that can mimic natural teeth and meet clinical needs are crucial. This review focuses on the current strategies and research advancements in enamel regeneration and dentin desensitization, and challenges of clinical translation. We emphasize that scientific research should start with clinical needs, and these studies, through translation, ultimately serve the clinic to form a mutually reinforcing virtuous cycle. This review aims to provide a new perspective on the prevention and treatment of dental hard tissues, promote innovation in restorative materials and techniques, and bring better clinical translation products and services to patients.

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来源期刊
Science China Materials
Science China Materials Materials Science-General Materials Science
CiteScore
11.40
自引率
7.40%
发文量
949
期刊介绍: Science China Materials (SCM) is a globally peer-reviewed journal that covers all facets of materials science. It is supervised by the Chinese Academy of Sciences and co-sponsored by the Chinese Academy of Sciences and the National Natural Science Foundation of China. The journal is jointly published monthly in both printed and electronic forms by Science China Press and Springer. The aim of SCM is to encourage communication of high-quality, innovative research results at the cutting-edge interface of materials science with chemistry, physics, biology, and engineering. It focuses on breakthroughs from around the world and aims to become a world-leading academic journal for materials science.
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