轻度抑郁症患者与非轻度抑郁症患者在动态情绪处理过程中的神经分歧:电影-核磁共振成像研究

Manqi Zhang, Mengjie Deng, Xiaowen Li, Rui Zhang, Jiejie Liao, Jun Peng, Huiyan Feng, Shixiong Tang, Yujie Chen, Lei Mo
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引用次数: 0

摘要

有关轻度抑郁症(MD)的神经病理学机制的研究非常有限,尤其是对有反复轻度抑郁发作史的人。本研究主要关注轻度抑郁症患者在处理现实生活中的情感刺激时出现的异常。研究人员招募了 32 名轻度抑郁症患者和 31 名正常对照组(NC),并对他们进行了全面的临床访谈、认知评估和磁共振成像(MRI)扫描。在功能磁共振成像扫描过程中,受试者观看了积极、消极和中性情绪电影片段。我们使用受试者间相关性和受试者间功能连接分析来研究 MD 和 NC 在观影过程中的神经分化。我们还分析了神经分化、症状严重程度和心理复原力之间的关系。我们发现,MD 和 NC 在扣带后皮层(PCC)和楔前皮层(PCUN)的神经分化在三种情绪条件下是一致的。值得注意的是,后扣带回皮层(PCC)和楔前区(PCUN)的神经反应与 NC(而非 MD)的相似性与抑郁症状呈负相关。此外,这种神经相似性对心理复原力和抑郁严重程度之间的关系起着中介作用。我们的研究结果表明,PCC 和 PCUN 是默认模式网络的两个核心区域,在 MD 的情绪处理缺陷中起着至关重要的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neural divergence between individuals with and without minor depression during dynamic emotion processing: a movie-fMRI Study.

Research on the neuropathological mechanisms underlying minor depression (MD), particularly in individuals with a history of recurrent minor depressive episodes, is very limited. This study focuses on the abnormality in processing real-life emotional stimuli among individuals with MD. Thirty-two individuals with MD and 31 normal controls (NC) were recruited and underwent comprehensive clinical interview, cognitive assessment, and magnetic resonance imaging (MRI) scans. During functional MRI scanning, subjects watched positive, negative, and neutral emotional movie clips. We used the inter-subject correlation and inter-subject functional connectivity analysis to investigate the neural differentiation between MD and NC during film viewing. The relationships between neural differentiation, symptom severity, and psychological resilience were analysed. We found that neural differentiations between individuals with MD and NC in the post cingulate cortex (PCC) and precuneus (PCUN) were consistent across three emotional conditions. Notably, the similarity of neural responses in the PCC and PCUN with NC but not MD was negatively correlated with depressive symptoms. Furthermore, this neural similarity mediated the relationship between psychological resilience and depression severity. Our findings support that the PCC and PCUN, two core areas of the default mode network, play a critical role in MD's emotion processing deficit.

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