评估门诊患者服用抗精神病药和抗抑郁药可能产生的药物相互作用。

IF 2 Q3 PHARMACOLOGY & PHARMACY
Pharmacy Pub Date : 2024-11-22 DOI:10.3390/pharmacy12060174
Iva Marović, Ivana Marinović, Vesna Bačić Vrca, Ivana Samardžić
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引用次数: 0

摘要

心理健康是维护整体健康的一个重要环节,也是一个重要的公共卫生问题。近代以来,精神疾病不断增多,通常需要复杂的药物治疗和长期监测。本研究旨在确定门诊环境中潜在精神药物相互作用的发生率和临床意义,并比较潜在药物相互作用(pDDIs)暴露与年龄的差异。精神药物包括抗精神病药-N05A、抗焦虑药-N05B、催眠药和镇静药-N05C,以及抗抑郁药-N06A。这项回顾性研究分析了 492 名接受过至少一种精神药物治疗的门诊患者的处方药物疗法。我们为每位患者开出了 1.64 种精神药物处方,并确定了 2.2 例涉及精神药物的帕金森病诊断。总共记录了 2285 例精神疾病分类,其中近一半(47.6%)为使用精神药物的精神疾病分类。在 65 岁以下的患者中发现了更多的处方精神药物,而在两个年龄组中发现了同等的精神药物剂量依赖性(p = 0.5077)。最常发现的 pDDIs 所涉及的精神药物是苯二氮卓、丙咪嗪和唑吡坦。结果表明,精神药物相互作用是初级保健中与药物相关的重要问题。精神药物的广泛使用及其相互作用的确定临床意义要求药剂师采取干预措施,以降低 pDDIs 的发生率并提高患者的安全性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Assessment of Potential Drug-Drug Interactions of Psycholeptics and Antidepressants in Outpatient Settings.

Mental health is an important segment in preserving overall health and represents a significant public health issue. In modern times, mental health disorders have risen, often requiring complex pharmacotherapy and chronic monitoring. The aim of this research was to determine the prevalence and clinical significance of potential psychotropic drug interactions in outpatient settings and compare the differences in potential drug-drug interaction (pDDIs) exposure with age. The psychotropic drugs included antipsychotics-N05A, anxiolytics-N05B, hypnotics and sedatives-N05C, and antidepressants-N06A. This retrospective study analyzed prescribed pharmacotherapy in 492 outpatients who were treated with at least one psychotropic drug. We determined 1.64 prescribed psychotropic drugs per patient and 2.2 pDDIs that involved psychotropic drugs. In total, 2285 pDDIs were recorded, of which almost half (47.6%) were pDDIs with psychotropic drugs. More prescribed psychotropic drugs were found in patients younger than 65 years, and equal exposure to pDDIs of psychotropic drugs (p = 0.5077) was found in both age groups. The most commonly identified psychotropics involved in pDDIs were benzodiazepines, promazine, and zolpidem. The results indicate that psychotropic drug interactions represent important drug-related problems for primary health care. The widespread use of psychotropic drugs and the determined clinical significance of their interactions require pharmacist interventions which can reduce the prevalence of pDDIs and increase patient safety.

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来源期刊
Pharmacy
Pharmacy PHARMACOLOGY & PHARMACY-
自引率
9.10%
发文量
141
审稿时长
11 weeks
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