{"title":"[双特异性和多特异性抗体药物的差异化发现策略]。","authors":"Dong Li","doi":"10.13345/j.cjb.240203","DOIUrl":null,"url":null,"abstract":"<p><p>Bispecific antibody drugs have enhanced efficacy and safety compared with therapeutic monoclonal antibody drugs, gradually becoming a new generation of effective therapies. With the development of genetic engineering and the maturity of the industry, increasing studies have been carried out on bispecific and multi-specific antibody drugs, and the application indications of these drugs are expanding, which lays a foundation for satisfying the clinical needs and creating clinical values. This paper provides a comprehensive review of the development stages, indications, target combinations, structural formats, and mechanisms of bispecific and multi-specific antibody drugs. It also discusses key points and strategies for differentiated drug discovery, facilitating the rapid development of innovative therapies, providing theoretical support for the clinical translation of these drugs, and offering more precise and effective treatment options for clinical practice.</p>","PeriodicalId":21778,"journal":{"name":"Sheng wu gong cheng xue bao = Chinese journal of biotechnology","volume":"40 11","pages":"3974-3984"},"PeriodicalIF":0.0000,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Differential discovery strategies of bispecific and multi-specific antibody drugs].\",\"authors\":\"Dong Li\",\"doi\":\"10.13345/j.cjb.240203\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Bispecific antibody drugs have enhanced efficacy and safety compared with therapeutic monoclonal antibody drugs, gradually becoming a new generation of effective therapies. With the development of genetic engineering and the maturity of the industry, increasing studies have been carried out on bispecific and multi-specific antibody drugs, and the application indications of these drugs are expanding, which lays a foundation for satisfying the clinical needs and creating clinical values. This paper provides a comprehensive review of the development stages, indications, target combinations, structural formats, and mechanisms of bispecific and multi-specific antibody drugs. It also discusses key points and strategies for differentiated drug discovery, facilitating the rapid development of innovative therapies, providing theoretical support for the clinical translation of these drugs, and offering more precise and effective treatment options for clinical practice.</p>\",\"PeriodicalId\":21778,\"journal\":{\"name\":\"Sheng wu gong cheng xue bao = Chinese journal of biotechnology\",\"volume\":\"40 11\",\"pages\":\"3974-3984\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-11-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Sheng wu gong cheng xue bao = Chinese journal of biotechnology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.13345/j.cjb.240203\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Biochemistry, Genetics and Molecular Biology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sheng wu gong cheng xue bao = Chinese journal of biotechnology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.13345/j.cjb.240203","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
[Differential discovery strategies of bispecific and multi-specific antibody drugs].
Bispecific antibody drugs have enhanced efficacy and safety compared with therapeutic monoclonal antibody drugs, gradually becoming a new generation of effective therapies. With the development of genetic engineering and the maturity of the industry, increasing studies have been carried out on bispecific and multi-specific antibody drugs, and the application indications of these drugs are expanding, which lays a foundation for satisfying the clinical needs and creating clinical values. This paper provides a comprehensive review of the development stages, indications, target combinations, structural formats, and mechanisms of bispecific and multi-specific antibody drugs. It also discusses key points and strategies for differentiated drug discovery, facilitating the rapid development of innovative therapies, providing theoretical support for the clinical translation of these drugs, and offering more precise and effective treatment options for clinical practice.
期刊介绍：
Chinese Journal of Biotechnology (Chinese edition) , sponsored by the Institute of Microbiology, Chinese Academy of Sciences and the Chinese Society for Microbiology, is a peer-reviewed international journal. The journal is cited by many scientific databases , such as Chemical Abstract (CA), Biology Abstract (BA), MEDLINE, Russian Digest , Chinese Scientific Citation Index (CSCI), Chinese Journal Citation Report (CJCR), and Chinese Academic Journal (CD version). The Journal publishes new discoveries, techniques and developments in genetic engineering, cell engineering, enzyme engineering, biochemical engineering, tissue engineering, bioinformatics, biochips and other fields of biotechnology.
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