乳腺癌和乳腺癌干细胞中的端粒酶抑制：简要回顾。

IF 2.8 4区医学 Q2 ONCOLOGY

Medical Oncology Pub Date : 2024-11-25 DOI:10.1007/s12032-024-02562-8

İrem Yildirim, Çığır Biray Avci

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引用次数: 0

摘要

乳腺癌是一个重大的健康问题，占所有女性癌症的三分之一。目前还没有治疗乳腺癌的确切方法，而且全世界的发病率逐年上升。此外，乳腺癌干细胞会对放疗和化疗产生抗药性。端粒酶是一种保护端粒的酶，在90%的癌细胞中被激活，端粒酶激活是癌症的标志。在这篇综述中，我们将研究乳腺癌和乳腺癌干细胞中端粒酶的活化以及抑制端粒酶对这些细胞的治疗效果。在这篇综述中，我们旨在强调端粒酶抑制在乳腺癌治疗中的重要性和影响，以及缺乏专门针对乳腺癌干细胞的研究。

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Telomerase inhibition in breast cancer and breast cancer stem cells: a brief review.

Breast cancer is a major health problem, accounting for one third of all cancers in women. There is no definitive treatment for breast cancer and its incidence is increasing worldwide every year. Furthermore, breast cancer stem cells cause resistance to radiation and chemotherapy. Telomerase is an enzyme that protects telomeres and is activated in 90% of cancer cells, and telomerase activation is a hallmark of cancer. In this review, we examine telomerase activation in breast cancer and breast cancer stem cells and the therapeutic effects of telomerase inhibition in these cells. In this review, we aim to highlight the importance and impact of telomerase inhibition in the treatment of breast cancer and the lack of studies specifically in breast cancer stem cells.

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来源期刊

Medical Oncology 医学-肿瘤学

CiteScore

4.20

自引率

2.90%

发文量

259

审稿时长

1.4 months

期刊介绍： Medical Oncology (MO) communicates the results of clinical and experimental research in oncology and hematology, particularly experimental therapeutics within the fields of immunotherapy and chemotherapy. It also provides state-of-the-art reviews on clinical and experimental therapies. Topics covered include immunobiology, pathogenesis, and treatment of malignant tumors.