肠道微生物群在炎症性肠病发病机制中的作用。

IF 2 4区医学 Q3 NUTRITION & DIETETICS

Journal of Clinical Biochemistry and Nutrition Pub Date : 2024-11-01 Epub Date: 2024-09-06 DOI:10.3164/jcbn.24-112

Yuji Naito, Tomohisa Takagi

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引用次数: 0

摘要

肠道微生物群，尤其是细菌群，在炎症性肠病（IBD）发病机制中的作用正变得越来越清晰。肠道微生物群分析的进步和使用生物碱模型突出了肠道细菌及其代谢产物在 IBD 进展过程中的重要性。粪便微生物群移植已在日本先进医疗 B 开始的溃疡性结肠炎临床试验中显示出前景，从而提高了人们对其结果的期望。这篇综述探讨了肠道微生物群在 IBD 中的作用，包括当前的知识和未来的前景。

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Role of gut microbiota in inflammatory bowel disease pathogenesis.

The role of the gut microbiota, especially bacterial flora, in the pathogenesis of inflammatory bowel disease (IBD) is becoming clearer. Advances in gut microbiota analysis and the use of gnotobiotics models have underscored the importance of gut bacteria and their metabolites in the progression of IBD. Fecal microbiota transplantation has shown promise in clinical trials for ulcerative colitis started as Advanced Medical Care B in Japan, raising expectations for its outcomes. This review explores the gut microbiota's role in IBD, encompassing both current knowledge and future prospects.

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来源期刊

Journal of Clinical Biochemistry and Nutrition 医学-营养学

CiteScore

4.30

自引率

8.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Journal of Clinical Biochemistry and Nutrition (JCBN) is an international, interdisciplinary publication encompassing chemical, biochemical, physiological, pathological, toxicological and medical approaches to research on lipid peroxidation, free radicals, oxidative stress and nutrition. The Journal welcomes original contributions dealing with all aspects of clinical biochemistry and clinical nutrition including both in vitro and in vivo studies.