血浆淀粉样蛋白-β 42/40的认知相关性的重要性。

IF 3.4 3区医学 Q2 NEUROSCIENCES

Journal of Alzheimer's Disease Pub Date : 2025-01-01 Epub Date: 2024-11-25 DOI:10.1177/13872877241301804

Andrea M Weinstein, Marissa A Gogniat, Meryl A Butters

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引用次数: 0

摘要

这篇评论的重点是 Curiel Cid 等人在最近一期《阿尔茨海默病杂志》（Journal of Alzheimer's Disease）上研究的血浆淀粉样蛋白-β（Aβ）42/40 对检测失忆性轻度认知障碍患者语义侵入错误的临床实用性。这篇评论强调了测试血浆 Aβ42/40 对临床症状敏感性的重要性，以寻求制定一个包含生物前体和临床后果的 AD 综合定义。

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The importance of cognitive correlates of plasma amyloid-β 42/40.

This commentary focuses on the clinical utility of plasma amyloid-β (Aβ) 42/40 to detect semantic intrusion errors in amnestic mild cognitive impairment, as investigated Curiel Cid et al. in a recent issue of the Journal of Alzheimer's Disease. This commentary highlights the importance of testing the sensitivity of plasma Aβ_42/40 to clinical symptoms in the quest to develop a comprehensive definition of AD that incorporates both biological precursors and clinical consequences.

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来源期刊

Journal of Alzheimer's Disease 医学-神经科学

CiteScore

6.40

自引率

7.50%

发文量

1327

审稿时长

2 months

期刊介绍： The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.