营养标记物与帕金森病和阿尔茨海默病的关联分析。

IF 3.4 3区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Heliyon Pub Date : 2024-11-06 eCollection Date: 2024-11-15 DOI:10.1016/j.heliyon.2024.e40191

Dong-Juan Xu, Yi-Lei Shen, Meng-Meng Hu, Ling-Ling Li, Yuan Fang, Ju-Ping He, Lu-Lu Ma, Shan-Shan Xu, Jian-Yong Wang

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引用次数: 0

摘要

导言：帕金森病（PD）和阿尔茨海默病（AD）是常见的神经退行性疾病，具有多方面的病因。帕金森病和阿尔茨海默病常与营养和代谢异常有关。在这项观察性研究中，我们分析了一系列营养指标，旨在了解它们与 AD 和 PD 风险的关系：方法：共纳入 424 名老年痴呆症患者、314 名注意力缺失症患者和 388 名健康对照者。测量的营养指标包括血红蛋白 A1c、维生素 B12、叶酸、载脂蛋白 B (ApoB)、载脂蛋白 A1 (ApoA1)、低密度脂蛋白 (LDL)、高密度脂蛋白、甘油三酯、总胆固醇 (TC)、尿酸和同型半胱氨酸 (HCY)。结果表明，多因素风险分析表明，甲胎蛋白（A）和高密度脂蛋白（LDL）的风险较高：多因素风险分析表明，载脂蛋白B、低密度脂蛋白和总胆固醇降低了髓鞘性白内障的风险，而同型半胱氨酸则增加了髓鞘性白内障的风险。载脂蛋白A1和HCY分别是AD的保护因素和危险因素：这项横断面研究表明，HCY 和脂质代谢指标与先天性痴呆症和注意力缺失症的风险有关。我们的研究结果支持一碳代谢和脂质代谢紊乱参与了帕金森氏症和阿德氏症的发病。

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Association analyses of nutritional markers with Parkinson's disease and Alzheimer's disease.

Introduction: Parkinson's disease (PD) and Alzheimer's disease (AD) are common neurodegenerative diseases with multifaceted etiology. Nutritional and metabolic abnormalities are frequently implicated in PD and AD. In this observational study, we analyzed a series of nutritional markers, and aimed to understand their association with AD and PD risk.

Methods: A total of 424 PD patients, 314 AD patients, and 388 healthy controls were included. Nutritional markers including Hemoglobin A1c, vitamin B12, folate, apolipoprotein B (ApoB), apolipoprotein A1 (ApoA1), low-density lipoprotein (LDL), high-density lipoprotein, triglyceride, total cholesterol (TC), uric acid and homocysteine (HCY) were measured. Significance for odds ratios examining was P < 0.0045 after bonferroni correction.

Results: Multifactor risk analysis showed that ApoB, LDL, and TC reduce PD risk, while HCY increase PD risk. ApoA1 and HCY are protective and risk factors for AD, respectively.

Conclusion: The cross-sectional study demonstrates that HCY and lipid metabolism markers are associated with PD and AD risks. Our findings support the involvement of one-carbon metabolism and lipid metabolism disturbance in PD and AD.

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来源期刊

Heliyon MULTIDISCIPLINARY SCIENCES-

CiteScore

4.50

自引率

2.50%

发文量

2793

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