{"title":"硫辛酸可抵御脂多糖抑制和内质网应激：GR7M/Homer/ATF6信号传导。","authors":"Mai O Kadry, Rehab M Abdel-Megeed","doi":"10.1080/20565623.2024.2422791","DOIUrl":null,"url":null,"abstract":"<p><p><b>Aim:</b> Endoplasmic reticulum stress triggers neuronal unfolded protein accumulation, contributing to the pathophysiology of depression psychiatric illnesses.<b>Materials & methods:</b> The brain-derived neurotrophic factor (<i>BDNF</i>), metabotropic glutamate receptor type 7 (<i>GRM7</i>), phosphoinisitol kinase-3 (<i>PIK3</i>), serine/threonine kinase 1 (<i>AKT</i>) and <i>Homer1</i> may afford an important signaling pathways in LPS induced depression rat model. Herein, thioctic acid, Burdock and propolis therapeutic index on lipopolysaccharide (LPS)-induced depression was monitored. <i>BDNF/PI3K/GR7M/ATF6/CHOP/XBP/AKT/Homer-1</i> signaling pathways also opened a novel avenue in the integration of synaptic neurotransmission.<b>Results:</b> The aforementioned treatments elevated GR7M/BDNF/GABA gene expression meanwhile decreased reactive oxygen species generation (Malondialdehyde/glutathione reductase/Total antioxidant capacity) and reduced the expression of <i>ATF6/CHOP/PI3K/AKT/XBP/Homer-1</i> post LPS elevation.<b>Conclusion:</b> Thioctic acid, propolis and Burdock are prospective therapeutic agents via <i>GRM7/BDNF/AKT/PI3K/ATF6/XBP/homer</i> -<i>1</i> signaling pathways in LPS-induced depression.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"2422791"},"PeriodicalIF":2.4000,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11591480/pdf/","citationCount":"0","resultStr":"{\"title\":\"Thioctic acid shield against lipopolysaccharide depression and endoplasmic reticulum stress: GR7M/Homer/ATF6 signaling.\",\"authors\":\"Mai O Kadry, Rehab M Abdel-Megeed\",\"doi\":\"10.1080/20565623.2024.2422791\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b>Aim:</b> Endoplasmic reticulum stress triggers neuronal unfolded protein accumulation, contributing to the pathophysiology of depression psychiatric illnesses.<b>Materials & methods:</b> The brain-derived neurotrophic factor (<i>BDNF</i>), metabotropic glutamate receptor type 7 (<i>GRM7</i>), phosphoinisitol kinase-3 (<i>PIK3</i>), serine/threonine kinase 1 (<i>AKT</i>) and <i>Homer1</i> may afford an important signaling pathways in LPS induced depression rat model. Herein, thioctic acid, Burdock and propolis therapeutic index on lipopolysaccharide (LPS)-induced depression was monitored. <i>BDNF/PI3K/GR7M/ATF6/CHOP/XBP/AKT/Homer-1</i> signaling pathways also opened a novel avenue in the integration of synaptic neurotransmission.<b>Results:</b> The aforementioned treatments elevated GR7M/BDNF/GABA gene expression meanwhile decreased reactive oxygen species generation (Malondialdehyde/glutathione reductase/Total antioxidant capacity) and reduced the expression of <i>ATF6/CHOP/PI3K/AKT/XBP/Homer-1</i> post LPS elevation.<b>Conclusion:</b> Thioctic acid, propolis and Burdock are prospective therapeutic agents via <i>GRM7/BDNF/AKT/PI3K/ATF6/XBP/homer</i> -<i>1</i> signaling pathways in LPS-induced depression.</p>\",\"PeriodicalId\":12568,\"journal\":{\"name\":\"Future Science OA\",\"volume\":\"10 1\",\"pages\":\"2422791\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2024-12-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11591480/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Future Science OA\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/20565623.2024.2422791\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/11/25 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Future Science OA","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/20565623.2024.2422791","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/11/25 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
Thioctic acid shield against lipopolysaccharide depression and endoplasmic reticulum stress: GR7M/Homer/ATF6 signaling.
Aim: Endoplasmic reticulum stress triggers neuronal unfolded protein accumulation, contributing to the pathophysiology of depression psychiatric illnesses.Materials & methods: The brain-derived neurotrophic factor (BDNF), metabotropic glutamate receptor type 7 (GRM7), phosphoinisitol kinase-3 (PIK3), serine/threonine kinase 1 (AKT) and Homer1 may afford an important signaling pathways in LPS induced depression rat model. Herein, thioctic acid, Burdock and propolis therapeutic index on lipopolysaccharide (LPS)-induced depression was monitored. BDNF/PI3K/GR7M/ATF6/CHOP/XBP/AKT/Homer-1 signaling pathways also opened a novel avenue in the integration of synaptic neurotransmission.Results: The aforementioned treatments elevated GR7M/BDNF/GABA gene expression meanwhile decreased reactive oxygen species generation (Malondialdehyde/glutathione reductase/Total antioxidant capacity) and reduced the expression of ATF6/CHOP/PI3K/AKT/XBP/Homer-1 post LPS elevation.Conclusion: Thioctic acid, propolis and Burdock are prospective therapeutic agents via GRM7/BDNF/AKT/PI3K/ATF6/XBP/homer -1 signaling pathways in LPS-induced depression.
期刊介绍：
Future Science OA is an online, open access, peer-reviewed title from the Future Science Group. The journal covers research and discussion related to advances in biotechnology, medicine and health. The journal embraces the importance of publishing all good-quality research with the potential to further the progress of research in these fields. All original research articles will be considered that are within the journal''s scope, and have been conducted with scientific rigour and research integrity. The journal also features review articles, editorials and perspectives, providing readers with a leading source of commentary and analysis. Submissions of the following article types will be considered: -Research articles -Preliminary communications -Short communications -Methodologies -Trial design articles -Trial results (including early-phase and negative studies) -Reviews -Perspectives -Commentaries
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