{"title":"针灸作为生活方式干预的辅助手段用于单纯性肥胖症患者的减肥：系统回顾与元分析》。","authors":"Xinyu Zhao, Yang Wang, Xiaoyi Li, Peiqun Hu, Xiong-Fei Pan, Benxiang He, Yunlu Liu, Yushi Hu, Tianmin Zhu","doi":"10.2147/DMSO.S484565","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This study aims to evaluate the efficacy of acupuncture as an adjunct to lifestyle interventions on weight loss in simple obesity.</p><p><strong>Methods: </strong>Potentially eligible studies that assessed anthropometric outcomes as well as glucose and lipid metabolism following acupuncture combined with lifestyle interventions in simple obesity patients were searched from eight databases from inception to October 2023. All analyses were performed using the Review Manager software v5.4 and Stata software v17.0.</p><p><strong>Results: </strong>Herein, 25 randomized controlled trials (RCTs) involving 2018 patients were included. Generally, acupuncture combined with lifestyle interventions outperformed lifestyle interventions alone in terms of body weight (MD = -4.73, 95% CI [-6.32, -3.13], <i>p</i> < 0.00001), body mass index (BMI) (MD = -2.11, 95% CI [-2.75, -1.48], <i>p</i> < 0.00001), waist circumference (WC) (MD = -4.96, 95% CI [-6.89, -3.03], <i>p</i> < 0.00001), body fat percentage (BF %) (MD = -2.61, 95% CI [-4,51, -0.71], <i>p</i> = 0.007), fasting plasma glucose (FPG) (SMD = -0.66, 95% CI [-1.02, -0.31], <i>p</i> = 0.0002), fasting serum insulin (FINS) (SMD = -1.12, 95% CI [-1.44, -0.81], <i>p</i> < 0.00001), homeostasis model assessment-insulin resistance (HOMA-IR) (MD = -1.22, 95% CI [-1.50, -0.94], <i>p</i> < 0.00001), total cholesterol (TC) (SMD = -1.14, 95% CI [-1.83, -0.45], <i>p</i> = 0.001), triglyceride (TG) (SMD = -1.31, 95% CI [-2.07, -0.56], <i>p</i> = 0.0006), and low-density lipoprotein cholesterol (LDL-C) (SMD = -1.81, 95% CI [-3.11, -0.51], <i>p</i> = 0.006). Subgroup analysis based on three subgroup variables (types of acupuncture and lifestyle interventions as well as treatment durations) could partially explain the heterogeneity of the results.</p><p><strong>Conclusion: </strong>Acupuncture demonstrated an enhancing effect on the benefits of lifestyle interventions for weight loss in patients with simple obesity, including reducing body weight and improving glucose and lipid metabolism. This finding suggests its potential value as a complementary therapy alongside lifestyle interventions in a clinical setting. However, further validation with rigorously designed and high-quality RCTs is still needed in the future.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"17 ","pages":"4319-4337"},"PeriodicalIF":2.8000,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11585983/pdf/","citationCount":"0","resultStr":"{\"title\":\"Acupuncture as an Adjunct to Lifestyle Interventions for Weight Loss in Simple Obesity: A Systematic Review and Meta-Analysis.\",\"authors\":\"Xinyu Zhao, Yang Wang, Xiaoyi Li, Peiqun Hu, Xiong-Fei Pan, Benxiang He, Yunlu Liu, Yushi Hu, Tianmin Zhu\",\"doi\":\"10.2147/DMSO.S484565\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>This study aims to evaluate the efficacy of acupuncture as an adjunct to lifestyle interventions on weight loss in simple obesity.</p><p><strong>Methods: </strong>Potentially eligible studies that assessed anthropometric outcomes as well as glucose and lipid metabolism following acupuncture combined with lifestyle interventions in simple obesity patients were searched from eight databases from inception to October 2023. All analyses were performed using the Review Manager software v5.4 and Stata software v17.0.</p><p><strong>Results: </strong>Herein, 25 randomized controlled trials (RCTs) involving 2018 patients were included. Generally, acupuncture combined with lifestyle interventions outperformed lifestyle interventions alone in terms of body weight (MD = -4.73, 95% CI [-6.32, -3.13], <i>p</i> < 0.00001), body mass index (BMI) (MD = -2.11, 95% CI [-2.75, -1.48], <i>p</i> < 0.00001), waist circumference (WC) (MD = -4.96, 95% CI [-6.89, -3.03], <i>p</i> < 0.00001), body fat percentage (BF %) (MD = -2.61, 95% CI [-4,51, -0.71], <i>p</i> = 0.007), fasting plasma glucose (FPG) (SMD = -0.66, 95% CI [-1.02, -0.31], <i>p</i> = 0.0002), fasting serum insulin (FINS) (SMD = -1.12, 95% CI [-1.44, -0.81], <i>p</i> < 0.00001), homeostasis model assessment-insulin resistance (HOMA-IR) (MD = -1.22, 95% CI [-1.50, -0.94], <i>p</i> < 0.00001), total cholesterol (TC) (SMD = -1.14, 95% CI [-1.83, -0.45], <i>p</i> = 0.001), triglyceride (TG) (SMD = -1.31, 95% CI [-2.07, -0.56], <i>p</i> = 0.0006), and low-density lipoprotein cholesterol (LDL-C) (SMD = -1.81, 95% CI [-3.11, -0.51], <i>p</i> = 0.006). Subgroup analysis based on three subgroup variables (types of acupuncture and lifestyle interventions as well as treatment durations) could partially explain the heterogeneity of the results.</p><p><strong>Conclusion: </strong>Acupuncture demonstrated an enhancing effect on the benefits of lifestyle interventions for weight loss in patients with simple obesity, including reducing body weight and improving glucose and lipid metabolism. This finding suggests its potential value as a complementary therapy alongside lifestyle interventions in a clinical setting. 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引用次数: 0
摘要
研究目的本研究旨在评估针灸作为生活方式干预的辅助手段对单纯性肥胖症患者减肥的疗效：从开始到 2023 年 10 月，在 8 个数据库中检索了评估单纯性肥胖患者针灸结合生活方式干预后人体测量结果以及葡萄糖和脂质代谢的潜在合格研究。所有分析均使用 Review Manager 软件 v5.4 和 Stata 软件 v17.0 进行：本文共纳入25项随机对照试验（RCT），涉及2018名患者。一般来说，在体重（MD = -4.73，95% CI [-6.32, -3.13]，p < 0.00001）、体重指数（BMI）（MD = -2.11，95% CI [-2.75，-1.48]，P < 0.00001）、腰围（WC）（MD = -4.96，95% CI [-6.89，-3.03]，P < 0.00001）、体脂百分比（BF %）（MD = -2.61，95% CI [-4，51，-0.71]，P = 0.007）、空腹血浆葡萄糖（FPG）（SMD = -0.66，95% CI [-1。02，-0.31]，P = 0.0002）、空腹血清胰岛素（FINS）（SMD =-1.12，95% CI [-1.44，-0.81]，P < 0.00001）、稳态模型评估-胰岛素抵抗（HOMA-IR）（MD =-1.22，95% CI [-1.50，-0.94]，P < 0.00001）、总胆固醇（TC）（SMD = -1.14, 95% CI [-1.83, -0.45]，P = 0.001）、甘油三酯（TG）（SMD = -1.31, 95% CI [-2.07, -0.56]，P = 0.0006）和低密度脂蛋白胆固醇（LDL-C）（SMD = -1.81, 95% CI [-3.11, -0.51]，P = 0.006）。基于三个亚组变量（针灸和生活方式干预的类型以及治疗持续时间）的亚组分析可以部分解释结果的异质性：结论：针灸对单纯性肥胖患者减肥的生活方式干预效果有增强作用，包括减轻体重、改善葡萄糖和脂质代谢。这一研究结果表明，在临床环境中，针灸作为生活方式干预的辅助疗法具有潜在价值。不过，今后仍需通过严格设计的高质量 RCT 进行进一步验证。
Acupuncture as an Adjunct to Lifestyle Interventions for Weight Loss in Simple Obesity: A Systematic Review and Meta-Analysis.
Objective: This study aims to evaluate the efficacy of acupuncture as an adjunct to lifestyle interventions on weight loss in simple obesity.
Methods: Potentially eligible studies that assessed anthropometric outcomes as well as glucose and lipid metabolism following acupuncture combined with lifestyle interventions in simple obesity patients were searched from eight databases from inception to October 2023. All analyses were performed using the Review Manager software v5.4 and Stata software v17.0.
Results: Herein, 25 randomized controlled trials (RCTs) involving 2018 patients were included. Generally, acupuncture combined with lifestyle interventions outperformed lifestyle interventions alone in terms of body weight (MD = -4.73, 95% CI [-6.32, -3.13], p < 0.00001), body mass index (BMI) (MD = -2.11, 95% CI [-2.75, -1.48], p < 0.00001), waist circumference (WC) (MD = -4.96, 95% CI [-6.89, -3.03], p < 0.00001), body fat percentage (BF %) (MD = -2.61, 95% CI [-4,51, -0.71], p = 0.007), fasting plasma glucose (FPG) (SMD = -0.66, 95% CI [-1.02, -0.31], p = 0.0002), fasting serum insulin (FINS) (SMD = -1.12, 95% CI [-1.44, -0.81], p < 0.00001), homeostasis model assessment-insulin resistance (HOMA-IR) (MD = -1.22, 95% CI [-1.50, -0.94], p < 0.00001), total cholesterol (TC) (SMD = -1.14, 95% CI [-1.83, -0.45], p = 0.001), triglyceride (TG) (SMD = -1.31, 95% CI [-2.07, -0.56], p = 0.0006), and low-density lipoprotein cholesterol (LDL-C) (SMD = -1.81, 95% CI [-3.11, -0.51], p = 0.006). Subgroup analysis based on three subgroup variables (types of acupuncture and lifestyle interventions as well as treatment durations) could partially explain the heterogeneity of the results.
Conclusion: Acupuncture demonstrated an enhancing effect on the benefits of lifestyle interventions for weight loss in patients with simple obesity, including reducing body weight and improving glucose and lipid metabolism. This finding suggests its potential value as a complementary therapy alongside lifestyle interventions in a clinical setting. However, further validation with rigorously designed and high-quality RCTs is still needed in the future.
期刊介绍：
An international, peer-reviewed, open access, online journal. The journal is committed to the rapid publication of the latest laboratory and clinical findings in the fields of diabetes, metabolic syndrome and obesity research. Original research, review, case reports, hypothesis formation, expert opinion and commentaries are all considered for publication.
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