骨髓细胞和脉冲微波对实验鼠热损伤皮肤的综合影响

IF 0.9 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-25 DOI:10.1007/s10517-024-06288-5

A V Samoylova, A A Gostyukhina, M A Bolshakov, V V Yartsev, S S Evseeva, O S Doroshenko, V M Mochalova, K V Zaitsev, O P Kutenkov, V V Rostov, G Ts Dambaev

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引用次数: 0

摘要

我们研究了骨髓细胞（BMC）和纳秒重复脉冲微波（RPMs，10 GHz，脉冲持续时间 100 nsec，脉冲重复率 8 Hz，峰值功率通量密度 (pPFD) 140 W/cm2）对大鼠热损伤皮肤再生的影响。BMC 和 RPMs 的联合使用加速了焦痂的分离，并在实验的第 14 天达到完全排斥。组织学分析表明，联合接触组肉芽组织的相对面积和新形成表皮的厚度都有显著增加。联合疗法可确保 100%的大鼠在研究的第 30 天完成伤口上皮化。

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Combined Effects of Bone Marrow Cells and Pulsed Microwaves on Thermally Damaged Skin of Laboratory Rats.

We studied the effect of bone marrow cells (BMC) and nanosecond repetitively pulsed microwaves (RPMs, 10 GHz, pulse duration 100 nsec, pulse repetition rate 8 Hz, peak power flux density (pPFD) 140 W/cm²) on the regeneration of thermally damaged skin in rats. The combined use of BMC and RPMs accelerates separation of an eschar with its complete rejection on day 14 of the experiment. Histological analysis demonstrated a statistically significant increase in the relative area of the granulation tissue and thickness of newly formed epidermis in the group with combined exposure. Combined therapy ensured completion of wound epithelialization in 100% of rats by day 30 of the study.

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.