EchiNam:关于比利时肺泡棘球蚴病诊断和治疗经验、挑战和陷阱的多中心回顾性研究。

IF 3.7 3区 医学 Q2 INFECTIOUS DISEASES
Pierre-Emmanuel Plum, Nathalie Ausselet, François Kidd, Séverine Noirhomme, Maria-Grazia Garrino, Alexandra Dili, Marie-Pierre Hayette, Olivier Detry, Philippe Leonard, Christian Motet, Maya Hites, Marc Bourgeois, Isabel Montesinos, Bénédicte Delaere
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引用次数: 0

摘要

研究目的这项回顾性研究旨在收集那慕尔医院网络(NHN)内诊断和/或随访的肺泡棘球蚴病(AE)病例的流行病学、临床、实验室、影像学、管理和随访数据,以收集有关诊断和治疗 AE 的挑战、陷阱和总体经验的信息:EchiNam 是一项多中心回顾性研究。研究纳入了 2002 年至 2023 年期间在 NHN 诊断和/或治疗可能或确诊为 AE 的患者。根据诊断代码、实验室结果和阿苯达唑(ABZ)配药情况选择患者:共检索到 22 例 AE 病例,其中 4 例被归类为可能病例,18 例被归类为确诊病例。九名患者要么没有症状,要么有其他疾病引起的症状。临床检查发现,10 名患者有病理结果。从首次出现 AE 提示性实验室异常到确诊的中位时间为 176 天,从首次出现 AE 相关影像异常到确诊的中位时间为 133 天。共有 12 名患者接受了手术切除,其中只有 4 人实现了病灶的完全切除。9名患者出现了与ABZ相关的不良反应,其中5人暂时停用了ABZ:结论:由于潜伏期长、比利时医生缺乏认识等各种因素,AE 通常在疾病晚期才被诊断出来。随后,治疗变得更加复杂甚至不理想,导致治疗时间延长、不良反应风险增加、生活质量明显下降、预后不良和死亡率升高。在疾病流行地区,应采取措施实现早期诊断。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
EchiNam: multicenter retrospective study on the experience, challenges, and pitfalls in the diagnosis and treatment of alveolar echinococcosis in Belgium.

Objectives: The aim of this retrospective study was to collect epidemiological, clinical, laboratory, imaging, management, and follow-up data on cases of alveolar echinococcosis (AE) diagnosed and/or followed up within the Namur Hospital Network (NHN) in order to gather information on the challenges, pitfalls, and overall experience in the diagnosis and treatment of AE.

Methods: EchiNam was a multicenter retrospective study. Patients diagnosed and/or treated for probable or confirmed AE in the NHN between 2002 and 2023 were included in the study. Patient selection was based on diagnosis codes, laboratory results, and albendazole (ABZ) dispensing.

Results: A total of 22 AE cases were retrieved, of which four were classified as probable and 18 as confirmed cases. Nine patients were either asymptomatic or had symptoms attributed to another disease. Clinical examination yielded pathologic findings in 10 patients. The median duration from the first AE-suggestive laboratory abnormalities to diagnosis was 176 days, and the median duration from the first AE-related imaging abnormalities to diagnosis was 133 days. Overall, 12 patients underwent surgical resection, with only four achieving complete lesion resection. Nine patients experienced ABZ-related adverse effects, with temporary ABZ discontinuation in five.

Conclusion: Due to various factors such as a long incubation period and a lack of awareness among Belgian physicians, AE is often diagnosed at advanced disease stages. Treatment then becomes more complex or even suboptimal, resulting in prolonged therapy, higher risk of adverse effects, significantly impaired quality of life, poor prognosis, and higher mortality rates. Measures should be taken to achieve early diagnosis in endemic areas.

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来源期刊
CiteScore
10.40
自引率
2.20%
发文量
138
审稿时长
1 months
期刊介绍: EJCMID is an interdisciplinary journal devoted to the publication of communications on infectious diseases of bacterial, viral and parasitic origin.
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