利用高频超声波对肝部分切除术后的门静脉狭窄进行分级:大鼠体内研究。

IF 1.4 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Diagnostic and interventional radiology Pub Date : 2025-03-03 Epub Date: 2024-11-25 DOI:10.4274/dir.2024.242912
Lin Ma, Chihan Peng, Lulu Yang, Xiaoxia Zhu, Hongxia Fan, Jiali Yang, Hong Wang, Yan Luo
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引用次数: 0

摘要

目的:评估超声波在70%肝部分切除术(PH)大鼠模型中分级门静脉狭窄(PVS)的诊断价值:方法:将96只Sprague-Dawley大鼠随机分为PH组和PVS组,PH组为轻度、中度和重度PVS。使用高频超声(5-12 MHz 高频线性换能器)测量血流动力学参数,包括狭窄前、狭窄和狭窄后门静脉直径(PVDpre、PVDs、PVDpost);狭窄前和狭窄后门静脉速度(PVVpre、PVVs);肝动脉收缩峰值速度(PSV);舒张末期速度;阻力指数。门静脉直径比(PVDR)和门静脉速度比(PVVR)用以下公式计算:PVDR=PVDpre/PVDs,PVVR=PVVs/PVVpre。评估了这些参数在分级 PVS 中的价值:结果:随着 PVS 的加重,门静脉血流动力学显示出梯度变化。对于识别 >50% PVS,PVDs 和 PVDR 是最佳参数,曲线下面积(AUC)分别为 0.85 和 0.86。在识别 >65% PVS 时,PVDs、PVDR 和 PVVR 相对较好,AUC 分别为 0.94、0.85 和 0.88。肝动脉 PSV 识别 >65% PVS 的 AUC 为 0.733:结论:高频超声造影可用于对大鼠的 PVS 进行分级,其中 PVDs、PVDR 和 PVVR 尤其有用。肝动脉 PSV 可能有助于预测 >65% 的 PVS。这些发现为 PVS 大鼠模型研究提供了有价值的信息,并为进一步研究活体肝移植(LDLT)中的 PVS 评估提供了实验基础:临床意义:超声波检查是诊断 LDLT 后 PVS 的一线技术。然而,PVS 严重程度的分级标准仍不明确。研究超声血流动力学在早期诊断 PVS 和狭窄严重程度分级中的应用对于术后早期干预和提高受者存活率非常重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Grading portal vein stenosis following partial hepatectomy by high-frequency ultrasonography: an in vivo study of rats.

Purpose: To evaluate the diagnostic value of ultrasound in grading portal vein stenosis (PVS) in a rat model of 70% partial hepatectomy (PH).

Methods: A total of 96 Sprague-Dawley rats were randomly divided into a PH group and PVS groups with mild, moderate, and severe PVS following PH. Hemodynamic parameters were measured using high-frequency ultrasound (5-12 MHz high-frequency linear transducer), including pre-stenotic, stenotic, and post-stenotic portal vein diameters (PVDpre, PVDs, PVDpost); pre-stenotic and stenotic portal vein velocity (PVVpre, PVVs); hepatic artery peak systolic velocity (PSV); end-diastolic velocity; and resistive index. The portal vein diameter ratio (PVDR) and portal vein velocity ratio (PVVR) were calculated using the following formulas: PVDR=PVDpre/PVDs and PVVR=PVVs/PVVpre. The value of these parameters in grading PVS was assessed.

Results: Portal vein hemodynamics showed gradient changes as PVS aggravated. For identifying >50% PVS, PVDs and PVDR were the best parameters, with areas under the curve (AUC) of 0.85 and 0.86, respectively. For identifying >65% PVS, PVDs, PVDR, and PVVR were relatively better, with AUCs of 0.94, 0.85, and 0.88, respectively. The AUC of hepatic artery PSV for identifying >65% PVS was 0.733.

Conclusion: High-frequency ultrasonography can be used to grade PVS in rats, with PVDs, PVDR, and PVVR being particularly useful. Hepatic artery PSV may help in predicting >65% PVS. These findings provide valuable information for PVS rat model research and offer an experimental basis for further studies on PVS evaluation in living-donor liver transplantation (LDLT).

Clinical significance: Ultrasonography serves as a first-line technology for diagnosing PVS following LDLT. However, the grading criteria for PVS severity remain unclear. Investigating the use of ultrasonic hemodynamics in the early diagnosis of PVS and grading stenosis severity is important for early postoperative intervention and improving recipient survival rates.

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来源期刊
Diagnostic and interventional radiology
Diagnostic and interventional radiology Medicine-Radiology, Nuclear Medicine and Imaging
自引率
4.80%
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期刊介绍: Diagnostic and Interventional Radiology (Diagn Interv Radiol) is the open access, online-only official publication of Turkish Society of Radiology. It is published bimonthly and the journal’s publication language is English. The journal is a medium for original articles, reviews, pictorial essays, technical notes related to all fields of diagnostic and interventional radiology.
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