儿童哮喘控制不佳的相关因素:预测模型

IF 2.3 4区 医学 Q3 ALLERGY
Wanaporn Anuntaseree, Kanokpan Ruangnapa, Araya Yuenyongviwat, Kantara Saelim, Pharsai Prasertsan
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引用次数: 0

摘要

背景:吸入皮质类固醇(ICS)是治疗小儿哮喘的一线疗法。然而,很少有研究开发出预测小儿哮喘治疗结果的简单工具:本研究旨在构建一个预测模型,用于预测儿童在接受 6 个月 ICS 治疗后哮喘控制不佳的情况:这项回顾性研究纳入了接受 ICS 治疗并完成 6 个月随访的 6-15 岁哮喘患儿。研究还评估了与哮喘控制不佳相关的潜在因素。根据全球哮喘倡议指南,如果儿童出现部分症状或症状未得到控制,则视为哮喘控制不佳:在165名符合条件的儿童中,有33名儿童(20%)症状控制不佳。与症状控制不佳相关的因素包括:在接受 ICS 治疗前的 12 个月内有过四次以上的症状加重史(比值比 [OR],3.39 [1.06,10.83])、在 6 个月的随访中出现中度至重度过敏性鼻炎症状(比值比,21.93 [2.97,162.05])以及哮喘药物治疗依从性差(比值比,4.16 [1.32,13.12])。通过纳入这些因素,构建了一个预测哮喘控制不佳的模型,并将其转换成一个总分为 200 分的提名图,预测风险范围为 0 至 100%。所建立模型的接收者操作特征曲线下面积为 0.737,表明其性能处于中等水平:结论:我们开发了一种哮喘控制不佳的预测工具。结论:我们开发了一种哮喘控制不佳的预测工具,该模型具有良好的判别能力,而且简单易用,有助于对哮喘儿童进行个体化管理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Factors associated with poor asthma control in children: A prediction model.

Background: Inhaled corticosteroids (ICS) are the first-line therapy for pediatric asthma. However, very few studies have developed simple tools for predicting treatment outcomes in pediatric asthma.

Objective: This study aimed to construct a predictive model for poor asthma control in children after 6 months of ICS therapy.

Methods: This retrospective study included children with asthma, aged 6-15 years, who received ICS with complete follow-up for 6 months. The potential factors associated with poor asthma control were also assessed. Poor control was considered if the child had partial or uncontrolled symptoms according to the Global Initiative for Asthma guidelines.

Results: Among the 165 eligible children, 33 (20%) had poor symptom control. The factors associated with poor control were a history of more than four exacerbations in the 12 months before ICS treatment (odds ratio [OR], 3.39 [1.06, 10.83]), the presence of moderate to severe allergic rhinitis symptoms at the 6-month follow-up visit (OR, 21.93 [2.97, 162.05]), and poor adherence to asthma medications (OR, 4.16 [1.32, 13.12]). By incorporating these factors, a model for predicting poorly controlled asthma was constructed and converted into a nomogram with a total score of 200, with prediction risk ranging from 0 to 100%. The area under the receiver operating characteristic curve of the developed model was 0.737, indicating a moderate performance level.

Conclusions: We developed a predictive tool for poor asthma control. The model has a good discriminatory ability and is simple to use, which could facilitate the individualized management of children with asthma.

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来源期刊
CiteScore
12.80
自引率
0.00%
发文量
74
审稿时长
>12 weeks
期刊介绍: The Asian Pacific Journal of Allergy and Immunology (APJAI) is an online open access journal with the recent impact factor (2018) 1.747 APJAI published 4 times per annum (March, June, September, December). Four issues constitute one volume. APJAI publishes original research articles of basic science, clinical science and reviews on various aspects of allergy and immunology. This journal is an official journal of and published by the Allergy, Asthma and Immunology Association, Thailand. The scopes include mechanism, pathogenesis, host-pathogen interaction, host-environment interaction, allergic diseases, immune-mediated diseases, epidemiology, diagnosis, treatment and prevention, immunotherapy, and vaccine. All papers are published in English and are refereed to international standards.
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