开发一种直接进样的超高效液相色谱-质谱/质谱法,用于定量检测路边蓄水池中的塑料添加剂化学品。

IF 3.8 2区 化学 Q1 BIOCHEMICAL RESEARCH METHODS
Katie McKenzie, Angela Pllu, Iain Campbell, Linda A Lawton, Bruce Petrie
{"title":"开发一种直接进样的超高效液相色谱-质谱/质谱法,用于定量检测路边蓄水池中的塑料添加剂化学品。","authors":"Katie McKenzie, Angela Pllu, Iain Campbell, Linda A Lawton, Bruce Petrie","doi":"10.1007/s00216-024-05657-3","DOIUrl":null,"url":null,"abstract":"<p><p>There is growing interest in road pollution that enters surface waters. Additive chemicals used in the manufacture of plastics, including tyre rubber, are mobile pollutants that pose a threat to aquatic life. Therefore, an ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) method was developed to measure 25 plastic additive chemicals in road runoff and water of retention ponds used to manage road runoff. A straightforward direct injection methodology was adopted to minimise sample handling and risk of contamination. Using this approach, the method quantitation limits (MQLs) ranged from 4.3 × 10<sup>-3</sup> to 13 µg/L. These were adequate to determine most chemicals at or below their freshwater predicted no-effect concentration (PNEC). Method trueness ranged from 18 to 148% with most chemicals being within 80-120%. The method was applied to water from four retention ponds in series to measure additive chemicals entering the ponds (i.e., in road runoff) and passing through each pond. Greatest concentrations were observed in road runoff during heavy rainfall following dry weather. Here, 1,3-diphenylguanidine (DPG) exceeded its current PNEC of 1.05 µg/L. Notably, N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine-quinone (6PPD-quinone) was determined at 0.13 µg/L which is greater than its lowest acute toxicity threshold (0.095 µg/L). Similarity in additive chemical concentrations throughout the retention ponds during steady flow suggests little or no removal occurs. However, further studies are needed to assess the fate and removal of plastic additive chemicals in retention ponds and the risk posed to aquatic environments. Such research can be facilitated by this newly developed UHPLC-MS/MS method.</p>","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":" ","pages":""},"PeriodicalIF":3.8000,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Development of a straightforward direct injection UHPLC-MS/MS method for quantification of plastic additive chemicals in roadside retention ponds.\",\"authors\":\"Katie McKenzie, Angela Pllu, Iain Campbell, Linda A Lawton, Bruce Petrie\",\"doi\":\"10.1007/s00216-024-05657-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>There is growing interest in road pollution that enters surface waters. Additive chemicals used in the manufacture of plastics, including tyre rubber, are mobile pollutants that pose a threat to aquatic life. Therefore, an ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) method was developed to measure 25 plastic additive chemicals in road runoff and water of retention ponds used to manage road runoff. A straightforward direct injection methodology was adopted to minimise sample handling and risk of contamination. Using this approach, the method quantitation limits (MQLs) ranged from 4.3 × 10<sup>-3</sup> to 13 µg/L. These were adequate to determine most chemicals at or below their freshwater predicted no-effect concentration (PNEC). Method trueness ranged from 18 to 148% with most chemicals being within 80-120%. The method was applied to water from four retention ponds in series to measure additive chemicals entering the ponds (i.e., in road runoff) and passing through each pond. Greatest concentrations were observed in road runoff during heavy rainfall following dry weather. Here, 1,3-diphenylguanidine (DPG) exceeded its current PNEC of 1.05 µg/L. Notably, N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine-quinone (6PPD-quinone) was determined at 0.13 µg/L which is greater than its lowest acute toxicity threshold (0.095 µg/L). Similarity in additive chemical concentrations throughout the retention ponds during steady flow suggests little or no removal occurs. However, further studies are needed to assess the fate and removal of plastic additive chemicals in retention ponds and the risk posed to aquatic environments. Such research can be facilitated by this newly developed UHPLC-MS/MS method.</p>\",\"PeriodicalId\":462,\"journal\":{\"name\":\"Analytical and Bioanalytical Chemistry\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.8000,\"publicationDate\":\"2024-11-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Analytical and Bioanalytical Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1007/s00216-024-05657-3\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMICAL RESEARCH METHODS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Analytical and Bioanalytical Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1007/s00216-024-05657-3","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
引用次数: 0

摘要

人们对进入地表水的道路污染越来越感兴趣。用于制造塑料(包括轮胎橡胶)的添加剂是对水生生物构成威胁的流动污染物。因此,我们开发了一种超高效液相色谱-串联质谱(UHPLC-MS/MS)方法,用于测量道路径流和用于管理道路径流的滞留池水中的 25 种塑料添加剂化学物质。该方法采用直接进样法,最大限度地减少了样品处理和污染风险。采用这种方法,方法定量限 (MQL) 从 4.3 × 10-3 到 13 µg/L 不等。这些限值足以在淡水预测无效应浓度 (PNEC) 或低于 PNEC 的情况下测定大多数化学物质。方法的准确度在 18% 到 148% 之间,大多数化学物质的准确度在 80% 到 120% 之间。该方法适用于四个系列滞留池塘的水,以测量进入池塘(即路面径流)并通过每个池塘的添加剂化学品。在干燥天气后的暴雨期间,路面径流中的浓度最高。其中,1,3-二苯基胍 (DPG) 超过了其目前的预测无效应浓度 1.05 µg/L。值得注意的是,N-(1,3-二甲基丁基)-N'-苯基-对苯二胺-醌(6PPD-quinone)的测定值为 0.13 微克/升,超过了其最低急性毒性阈值(0.095 微克/升)。在稳定水流期间,整个滞留池的添加剂化学浓度相似,这表明几乎没有或根本没有去除。不过,还需要进一步研究,以评估塑料添加剂化学品在滞留池塘中的归宿和去除情况,以及对水生环境造成的风险。这种新开发的超高效液相色谱-质谱/质谱方法将有助于此类研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Development of a straightforward direct injection UHPLC-MS/MS method for quantification of plastic additive chemicals in roadside retention ponds.

There is growing interest in road pollution that enters surface waters. Additive chemicals used in the manufacture of plastics, including tyre rubber, are mobile pollutants that pose a threat to aquatic life. Therefore, an ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) method was developed to measure 25 plastic additive chemicals in road runoff and water of retention ponds used to manage road runoff. A straightforward direct injection methodology was adopted to minimise sample handling and risk of contamination. Using this approach, the method quantitation limits (MQLs) ranged from 4.3 × 10-3 to 13 µg/L. These were adequate to determine most chemicals at or below their freshwater predicted no-effect concentration (PNEC). Method trueness ranged from 18 to 148% with most chemicals being within 80-120%. The method was applied to water from four retention ponds in series to measure additive chemicals entering the ponds (i.e., in road runoff) and passing through each pond. Greatest concentrations were observed in road runoff during heavy rainfall following dry weather. Here, 1,3-diphenylguanidine (DPG) exceeded its current PNEC of 1.05 µg/L. Notably, N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine-quinone (6PPD-quinone) was determined at 0.13 µg/L which is greater than its lowest acute toxicity threshold (0.095 µg/L). Similarity in additive chemical concentrations throughout the retention ponds during steady flow suggests little or no removal occurs. However, further studies are needed to assess the fate and removal of plastic additive chemicals in retention ponds and the risk posed to aquatic environments. Such research can be facilitated by this newly developed UHPLC-MS/MS method.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
8.00
自引率
4.70%
发文量
638
审稿时长
2.1 months
期刊介绍: Analytical and Bioanalytical Chemistry’s mission is the rapid publication of excellent and high-impact research articles on fundamental and applied topics of analytical and bioanalytical measurement science. Its scope is broad, and ranges from novel measurement platforms and their characterization to multidisciplinary approaches that effectively address important scientific problems. The Editors encourage submissions presenting innovative analytical research in concept, instrumentation, methods, and/or applications, including: mass spectrometry, spectroscopy, and electroanalysis; advanced separations; analytical strategies in “-omics” and imaging, bioanalysis, and sampling; miniaturized devices, medical diagnostics, sensors; analytical characterization of nano- and biomaterials; chemometrics and advanced data analysis.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信