Josiane Rodrigues Rocha da Silva, Camila Oliveira de Andrade, Anna Carla Ribeiro, Paula Derksen Macruz, Elizabeth da Costa Neves FernandesAlmeida Duarte, Rosângela Bergamasco, Ana Luiza de Brito Portela-Castro, Carlos Alexandre Fernandes
{"title":"评估银纳米颗粒（NZ-AgNPs）功能化天然沸石（NZ）对黄尾四大家鱼（Astyanax lacustris）红细胞的细胞毒性和遗传毒性的体内试验。","authors":"Josiane Rodrigues Rocha da Silva, Camila Oliveira de Andrade, Anna Carla Ribeiro, Paula Derksen Macruz, Elizabeth da Costa Neves FernandesAlmeida Duarte, Rosângela Bergamasco, Ana Luiza de Brito Portela-Castro, Carlos Alexandre Fernandes","doi":"10.1007/s12011-024-04451-7","DOIUrl":null,"url":null,"abstract":"<p><p>Silver nanoparticles (AgNPs) have unique properties such as chemical stability, malleability, flexibility, high electrical and thermal conductivity, and catalytic activity, making them suitable for various applications. However, they also pose potential toxicity and environmental contamination risks. Natural zeolites (NZs) are considered excellent inorganic support for reducing the toxicity of AgNPs. The scope of this study was to carry out a comparative assessment of the cytotoxic and genotoxic effects of NZ, NZ functionalized with silver nanoparticles (NZ-AgNPs), and commercial AgNPs on fish Astyanax lacustris. Micronucleus (MN) test, cellular morphological change (CMC) test, and the comet assay were used to assess the effects of the nanoparticles. A. lacustris specimens were exposed to a concentrations of 0.1 mg l<sup>-1</sup> in the NZs, NZ-AgNPs, and commercial AgNPs for 96 h during the experiment. The results showed no significant difference between the negative control and NZ. Moreover, NZ-AgNPs exhibited reduced toxicities compared to commercial AgNPs, which caused higher levels of alterations and cellular damage. The study concluded that NZs effectively reduced cytotoxicity/genotoxicity in A. lacustris specimens when used to support AgNPs.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4000,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"In Vivo Test to Evaluate the Cytotoxicity and Genotoxicity of Natural Zeolite (NZ) Functionalized with Silver Nanoparticles (NZ-AgNPs) on Erythrocytes of Yellowtail Tetra Fish Astyanax lacustris.\",\"authors\":\"Josiane Rodrigues Rocha da Silva, Camila Oliveira de Andrade, Anna Carla Ribeiro, Paula Derksen Macruz, Elizabeth da Costa Neves FernandesAlmeida Duarte, Rosângela Bergamasco, Ana Luiza de Brito Portela-Castro, Carlos Alexandre Fernandes\",\"doi\":\"10.1007/s12011-024-04451-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Silver nanoparticles (AgNPs) have unique properties such as chemical stability, malleability, flexibility, high electrical and thermal conductivity, and catalytic activity, making them suitable for various applications. However, they also pose potential toxicity and environmental contamination risks. Natural zeolites (NZs) are considered excellent inorganic support for reducing the toxicity of AgNPs. The scope of this study was to carry out a comparative assessment of the cytotoxic and genotoxic effects of NZ, NZ functionalized with silver nanoparticles (NZ-AgNPs), and commercial AgNPs on fish Astyanax lacustris. Micronucleus (MN) test, cellular morphological change (CMC) test, and the comet assay were used to assess the effects of the nanoparticles. A. lacustris specimens were exposed to a concentrations of 0.1 mg l<sup>-1</sup> in the NZs, NZ-AgNPs, and commercial AgNPs for 96 h during the experiment. The results showed no significant difference between the negative control and NZ. Moreover, NZ-AgNPs exhibited reduced toxicities compared to commercial AgNPs, which caused higher levels of alterations and cellular damage. The study concluded that NZs effectively reduced cytotoxicity/genotoxicity in A. lacustris specimens when used to support AgNPs.</p>\",\"PeriodicalId\":8917,\"journal\":{\"name\":\"Biological Trace Element Research\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2024-11-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biological Trace Element Research\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1007/s12011-024-04451-7\",\"RegionNum\":3,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biological Trace Element Research","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1007/s12011-024-04451-7","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
In Vivo Test to Evaluate the Cytotoxicity and Genotoxicity of Natural Zeolite (NZ) Functionalized with Silver Nanoparticles (NZ-AgNPs) on Erythrocytes of Yellowtail Tetra Fish Astyanax lacustris.
Silver nanoparticles (AgNPs) have unique properties such as chemical stability, malleability, flexibility, high electrical and thermal conductivity, and catalytic activity, making them suitable for various applications. However, they also pose potential toxicity and environmental contamination risks. Natural zeolites (NZs) are considered excellent inorganic support for reducing the toxicity of AgNPs. The scope of this study was to carry out a comparative assessment of the cytotoxic and genotoxic effects of NZ, NZ functionalized with silver nanoparticles (NZ-AgNPs), and commercial AgNPs on fish Astyanax lacustris. Micronucleus (MN) test, cellular morphological change (CMC) test, and the comet assay were used to assess the effects of the nanoparticles. A. lacustris specimens were exposed to a concentrations of 0.1 mg l-1 in the NZs, NZ-AgNPs, and commercial AgNPs for 96 h during the experiment. The results showed no significant difference between the negative control and NZ. Moreover, NZ-AgNPs exhibited reduced toxicities compared to commercial AgNPs, which caused higher levels of alterations and cellular damage. The study concluded that NZs effectively reduced cytotoxicity/genotoxicity in A. lacustris specimens when used to support AgNPs.
期刊介绍：
Biological Trace Element Research provides a much-needed central forum for the emergent, interdisciplinary field of research on the biological, environmental, and biomedical roles of trace elements. Rather than confine itself to biochemistry, the journal emphasizes the integrative aspects of trace metal research in all appropriate fields, publishing human and animal nutritional studies devoted to the fundamental chemistry and biochemistry at issue as well as to the elucidation of the relevant aspects of preventive medicine, epidemiology, clinical chemistry, agriculture, endocrinology, animal science, pharmacology, microbiology, toxicology, virology, marine biology, sensory physiology, developmental biology, and related fields.
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