食管鳞状细胞癌血清可溶性程序性死亡 1 (sPD-1) 和程序性死亡配体 1 (sPD-L1) 的预后价值：关于队列研究的系统综述和荟萃分析

IF 2.1 Q2 MEDICINE, GENERAL & INTERNAL

Health Science Reports Pub Date : 2024-11-25 DOI:10.1002/hsr2.70178

Qiyao Yu, Jie Li, Wenjie Mao, Zheng Li, Xuan Li, Bin Li

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引用次数: 0

摘要

背景和目的目前尚无有效的生物标志物用于预测食管鳞状细胞癌（ESCC）的预后。在某些癌症的预后中，可溶性程序性死亡1（sPD-1）和程序性死亡配体1（sPD-L1）具有统计学意义，但血清sPD-L1和sPD-1在ESCC中的预后价值仍不明确。方法在此，我们进行了一项荟萃分析，以估计 sPD-L1 和 sPD-1 在 ESCC 中的预后价值。为了获得符合条件的研究，我们检索了主流数据库（PubMed、Cochrane、Embase、Web of Science、万方数据和 CNKI），并从纳入的文献中提取了包括危险比（HR）及其 95% 置信区间（95% CI）在内的生存数据。结果共纳入6篇文章，包括645名ESCC患者。荟萃分析的统计结果表明，血清sPD-1与ESCC患者的总生存率（OS）无显著相关性（p > 0.05）。血清 sPD-L1 浓度较高的 ESCC 患者预后明显较差（HR = 1.73，95% CI：1.42-2.11，p < 0.001）。结论血清sPD-L1水平较高可预测ESCC患者较差的OS，这可能是食管癌一种有希望的、可信的预后生物标志物。

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The Prognostic Value of Serum Soluble Programmed Death 1 (sPD-1) and Programmed Death Ligand 1 (sPD-L1) in Esophageal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis About Cohort Studies

Background and Aims

There are still no useful biomarkers for the prognosis of esophageal squamous cell carcinoma (ESCC). In the prognosis of some kinds of cancer, soluble programmed death 1 (sPD-1) and programmed death ligand 1 (sPD-L1) have demonstrated statistical significance, but the prognostic value of serum sPD-L1 and sPD-1 remains unclear in ESCC.

Methods

Here, a meta-analysis was performed to estimate the prognostic value of sPD-L1 and sPD-1 in ESCC. To obtain eligible studies, we searched mainstream databases (PubMed, Cochrane, Embase, Web of Science, Wanfang Data, and CNKI), and the survival data including hazard ratios (HR) and its 95% confidence intervals (95% CI) from included literature were extracted.

Results

Six articles were included, including 645 patients with ESCC. The statistical result of this meta-analysis indicated that serum sPD-1 had no significant correlation with overall survival (OS) of patients with ESCC (p > 0.05). Patients with ESCC with high concentrations of serum sPD-L1 demonstrated a significantly poor prognosis (HR = 1.73, 95% CI: 1.42–2.11, p < 0.001).