Bexagliflozin 的高效简便合成：一种 SGLT-2 抑制剂

IF 1.9 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

ChemistrySelect Pub Date : 2024-11-21 DOI:10.1002/slct.202404188

Govinda G Krishna Kilaru, Ramakanth Pagadala, Madhusudan Gutta, Chandra Shekar Kondabattula, S. T. Rajkumar, Sreedhar Gundekari, Mohan Varkolu

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引用次数: 0

摘要

一种制备贝沙格列净 (1) 的新合成方法，贝沙格列净是钠依赖性葡萄糖共转运体 2 (SGLT-2) 的选择性抑制剂，用于治疗 2 型糖尿病。这种新方法设计简单、环保，采用创新的中间体，可高效生产化合物 (1)。本文详细介绍了评估这种先进的可扩展合成路线的实验程序。该工艺的主要特点包括使用市场上可买到且易于管理的试剂、减少反应步骤以及最大限度地减少废物的产生。这种方法不仅提高了合成效率，而且符合可持续化学实践。

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Efficient and Facile Synthesis of Bexagliflozin: An SGLT-2 Inhibitor

A novel synthetic approach for the preparation of bexagliflozin (1), a selective inhibitor of sodium-dependent glucose cotransporter 2 (SGLT-2) utilized in the management of type 2 diabetes. This new method is designed to be simple and environmentally friendly, employing innovative intermediates and offering high efficiency in the production of compound (1). The paper details the experimental procedures undertaken to assess this advanced and scalable synthetic route. Key features of the process include the use of commercially available and easily manageable reagents, reduced reaction steps, and minimized waste generation. This approach not only enhances the efficiency of the synthesis but also aligns with sustainable chemical practices.

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来源期刊

ChemistrySelect Chemistry-General Chemistry

CiteScore

3.30

自引率

4.80%

发文量

1809

审稿时长

1.6 months

期刊介绍： ChemistrySelect is the latest journal from ChemPubSoc Europe and Wiley-VCH. It offers researchers a quality society-owned journal in which to publish their work in all areas of chemistry. Manuscripts are evaluated by active researchers to ensure they add meaningfully to the scientific literature, and those accepted are processed quickly to ensure rapid online publication.