Won-Pyo Lee , Euisin Yang , Woong Kim , Riessa Nanda Mertamani , Hana Lee , Se Eun Kim , Kyung Mi Shim , Seong Soo Kang , Sukyoung Kim , Seok-Jun Kim , Jooseong Kim
{"title":"磷酸八钙和水玻璃的协同组合改善骨再生效果","authors":"Won-Pyo Lee , Euisin Yang , Woong Kim , Riessa Nanda Mertamani , Hana Lee , Se Eun Kim , Kyung Mi Shim , Seong Soo Kang , Sukyoung Kim , Seok-Jun Kim , Jooseong Kim","doi":"10.1016/j.matdes.2024.113484","DOIUrl":null,"url":null,"abstract":"<div><div>Octacalcium phosphate (OCP) is a precursor of biological apatite minerals that can be used in synthetic bone grafts. In this work, a new type of synthetic bone grafts was developed by adding water glass to OCP (W-OCP). The OCP phase is generally known to be thermodynamically unstable and rapidly hydrolyzes to apatite. However, X-ray diffraction confirmed that OCP can remain stable even in the presence of water glass. In a rabbit calvarial defect model, W-OCP increased the bone area by 22.4 %, which was significantly higher than that of defects only at week 4 (p < 0.05). In clinical trials, the new bone formation rate was 49.5 %, confirming that W-OCP had an extremely high application potential as a new bone graft material. After treating MG-63 cells with a W-OCP elution medium, changes in gene expression levels that promoted bone formation were verified via microarray analysis. From the results, W-OCP can be inferred that sodium and silicate ions in water glass play an important role in the recruitment of osteoblasts, significantly increasing the bone growth rate at the early implantation stages. The obtained results suggest that W-OCP can be potentially applied as a new type of synthetic bone materials.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"248 ","pages":"Article 113484"},"PeriodicalIF":7.6000,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Improvement of bone regeneration by a synergistic combination of octacalcium phosphate and water glass\",\"authors\":\"Won-Pyo Lee , Euisin Yang , Woong Kim , Riessa Nanda Mertamani , Hana Lee , Se Eun Kim , Kyung Mi Shim , Seong Soo Kang , Sukyoung Kim , Seok-Jun Kim , Jooseong Kim\",\"doi\":\"10.1016/j.matdes.2024.113484\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Octacalcium phosphate (OCP) is a precursor of biological apatite minerals that can be used in synthetic bone grafts. In this work, a new type of synthetic bone grafts was developed by adding water glass to OCP (W-OCP). The OCP phase is generally known to be thermodynamically unstable and rapidly hydrolyzes to apatite. However, X-ray diffraction confirmed that OCP can remain stable even in the presence of water glass. In a rabbit calvarial defect model, W-OCP increased the bone area by 22.4 %, which was significantly higher than that of defects only at week 4 (p < 0.05). In clinical trials, the new bone formation rate was 49.5 %, confirming that W-OCP had an extremely high application potential as a new bone graft material. After treating MG-63 cells with a W-OCP elution medium, changes in gene expression levels that promoted bone formation were verified via microarray analysis. From the results, W-OCP can be inferred that sodium and silicate ions in water glass play an important role in the recruitment of osteoblasts, significantly increasing the bone growth rate at the early implantation stages. The obtained results suggest that W-OCP can be potentially applied as a new type of synthetic bone materials.</div></div>\",\"PeriodicalId\":383,\"journal\":{\"name\":\"Materials & Design\",\"volume\":\"248 \",\"pages\":\"Article 113484\"},\"PeriodicalIF\":7.6000,\"publicationDate\":\"2024-11-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Materials & Design\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0264127524008591\",\"RegionNum\":2,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materials & Design","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0264127524008591","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
Improvement of bone regeneration by a synergistic combination of octacalcium phosphate and water glass
Octacalcium phosphate (OCP) is a precursor of biological apatite minerals that can be used in synthetic bone grafts. In this work, a new type of synthetic bone grafts was developed by adding water glass to OCP (W-OCP). The OCP phase is generally known to be thermodynamically unstable and rapidly hydrolyzes to apatite. However, X-ray diffraction confirmed that OCP can remain stable even in the presence of water glass. In a rabbit calvarial defect model, W-OCP increased the bone area by 22.4 %, which was significantly higher than that of defects only at week 4 (p < 0.05). In clinical trials, the new bone formation rate was 49.5 %, confirming that W-OCP had an extremely high application potential as a new bone graft material. After treating MG-63 cells with a W-OCP elution medium, changes in gene expression levels that promoted bone formation were verified via microarray analysis. From the results, W-OCP can be inferred that sodium and silicate ions in water glass play an important role in the recruitment of osteoblasts, significantly increasing the bone growth rate at the early implantation stages. The obtained results suggest that W-OCP can be potentially applied as a new type of synthetic bone materials.
期刊介绍:
Materials and Design is a multi-disciplinary journal that publishes original research reports, review articles, and express communications. The journal focuses on studying the structure and properties of inorganic and organic materials, advancements in synthesis, processing, characterization, and testing, the design of materials and engineering systems, and their applications in technology. It aims to bring together various aspects of materials science, engineering, physics, and chemistry.
The journal explores themes ranging from materials to design and aims to reveal the connections between natural and artificial materials, as well as experiment and modeling. Manuscripts submitted to Materials and Design should contain elements of discovery and surprise, as they often contribute new insights into the architecture and function of matter.