Askar K. Gatiatulin, Marat A. Ziganshin, Valery V. Gorbatchuk
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引用次数: 0
摘要
在许多工业应用中,环糊精(CD)与药物、食品添加剂、染料和香精油成分的包合物的制备都是在固体混合物、泥浆或糊状体系中进行的,由于缺乏水,环糊精和客体无法完全溶解。与水溶液中环糊精络合的经典分析相比,这类体系需要不同的描述。固态客体包合物的主要特征是从固态 CD 到固态包合物的相变。这意味着客体包合的尺寸排斥效应、水或有机化合物等第三成分对这一过程的协同激活以及客体和水对 CD 晶格内部空间的竞争之间存在着复杂的相互作用。本综述总结了固态原生 CD 对客体包裹的研究现状,并比较了这一过程的驱动力及其与水溶液中络合的结构-性质关系。为了进行充分的比较,我们以热力学活性为尺度对后一过程进行了分析,从而将疏水效应与客体分子形状和 "高能 "水等影响络合物稳定性的重要因素区分开来。
Guest inclusion by native cyclodextrins in solid state and solutions: A review
In many industrial applications, preparation of cyclodextrin (CD) inclusion complexes with drugs, food additives, dyes and components of essence oils is performed in solid mixtures, slurries or paste-like systems having lack of water to dissolve cyclodextrin and guest completely. Such systems need a different description than supplied by classical analysis of CD complexation in aqueous solutions. The main feature of solid-state guest inclusion is the phase transition from solid CD to solid inclusion compound. This implies a complex interplay between a size exclusion effect for guest inclusion, a cooperative activation of this process by the third component such as water or organic compound and competition of guest and water for the space inside CD crystal lattice. The present review summarizes the current state of research of guest inclusion by native CDs in solid state and compares the driving forces of this process and its structure-property relationships with those of complexation in aqueous solutions. For an adequate comparison, the latter process was analyzed in thermodynamic activity scale, which allowed to separate hydrophobic effect and such important factors of complex stability as guest molecular shape and “high-energy” water.
期刊介绍:
Carbohydrate Polymers stands as a prominent journal in the glycoscience field, dedicated to exploring and harnessing the potential of polysaccharides with applications spanning bioenergy, bioplastics, biomaterials, biorefining, chemistry, drug delivery, food, health, nanotechnology, packaging, paper, pharmaceuticals, medicine, oil recovery, textiles, tissue engineering, wood, and various aspects of glycoscience.
The journal emphasizes the central role of well-characterized carbohydrate polymers, highlighting their significance as the primary focus rather than a peripheral topic. Each paper must prominently feature at least one named carbohydrate polymer, evident in both citation and title, with a commitment to innovative research that advances scientific knowledge.