从毛霉 18F0056 培养基中提取天然产物并评估其抗真菌特性

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2024-11-25 DOI:10.1016/j.phytol.2024.10.009

Ming-Jen Cheng , Jih-Jung Chen , Hsia-Wei Liu , Ming-Der Wu , Yu-Hui Wei , Guey-Yuh Liou , Min Tseng

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引用次数: 0

摘要

从毛霉 18F0056 的培养液中的乙酸乙酯可溶部分分离出了两种以前未曾描述过的铬酮衍生物 1 和 2。根据对光谱数据的大量分析以及与文献数据的比较，阐明了它们的结构。同时还对它们的抗真菌活性进行了评估。结果表明，这两种成分对镰刀菌 LC8、新孢子菌 BCRC 35002 和球孢子菌 Colletotrichum gloeosporioides BCRC 35178 具有微弱的抗真菌活性。过去，毛霉属很少发现铬酮衍生物。此次对毛霉新种产品的研究意义重大。毛霉天然产物作为生物防治的抗真菌剂值得进一步评估。

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Extraction and assessment of antifungal properties of natural products from the culture medium of Trichoderma sp. 18F0056

Two previously undescribed chromone derivatives, 1 and 2, were isolated from the EtOAc-soluble fraction of the culture broth of Trichoderma sp. 18F0056. Their structures were elucidated on the basis of extensive analyses of spectroscopic data and comparison with literature data. Their antifungal activity was also evaluated. Our results showed that both constituents possessed weak antifungal activity against Fusarium sp. LC8, Neopestalotiopsis sp. BCRC 35002, and Colletotrichum gloeosporioides BCRC 35178. In the past, chromone derivatives were rarely found from the genus Trichoderma. This time, the research on the products of this new species of Trichoderma is of significant significance. Trichoderma natural products deserve further evaluation as anti-fungal agents for biocontrol.

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.