细胞癌变过程中代谢和表观遗传修饰之间的相互影响

IF 4.6 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

iScience Pub Date : 2024-11-15 DOI:10.1016/j.isci.2024.111359

Yue Gao , Siyu zhang , Xianhong Zhang , Yitian Du , Ting Ni , Shuailin Hao

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引用次数: 0

摘要

各种内部和外部因素导致的基因突变促使细胞癌变。癌细胞会发生许多变化，包括代谢重编程和表观遗传修饰，以支持其异常增殖。这种新陈代谢重编程导致许多新陈代谢酶的表达改变和代谢产物的积累。最近的研究表明，这些酶和代谢物可作为染色质修饰酶的底物或辅助因子，从而参与表观遗传修饰并促进癌变。此外，表观遗传修饰还在癌细胞的代谢重编程和免疫逃避中发挥作用，影响癌症的进展。本综述侧重于癌症的起源，特别是癌细胞的代谢重编程和表观遗传修饰的变化。我们将讨论癌细胞中的代谢物如何促进表观遗传学重塑，包括乳酰化、乙酰化、琥珀酰化和巴豆酰化。最后，我们回顾了表观遗传修饰对肿瘤免疫的影响以及针对这些修饰的癌症疗法的最新进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Crosstalk between metabolic and epigenetic modifications during cell carcinogenesis

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Crosstalk between metabolic and epigenetic modifications during cell carcinogenesis

Genetic mutations arising from various internal and external factors drive cells to become cancerous. Cancerous cells undergo numerous changes, including metabolic reprogramming and epigenetic modifications, to support their abnormal proliferation. This metabolic reprogramming leads to the altered expression of many metabolic enzymes and the accumulation of metabolites. Recent studies have shown that these enzymes and metabolites can serve as substrates or cofactors for chromatin-modifying enzymes, thereby participating in epigenetic modifications and promoting carcinogenesis. Additionally, epigenetic modifications play a role in the metabolic reprogramming and immune evasion of cancer cells, influencing cancer progression. This review focuses on the origins of cancer, particularly the metabolic reprogramming of cancer cells and changes in epigenetic modifications. We discuss how metabolites in cancer cells contribute to epigenetic remodeling, including lactylation, acetylation, succinylation, and crotonylation. Finally, we review the impact of epigenetic modifications on tumor immunity and the latest advancements in cancer therapies targeting these modifications.

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来源期刊

iScience Multidisciplinary-Multidisciplinary

CiteScore

7.20

自引率

1.70%

发文量

1972

审稿时长

6 weeks

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