姜黄素修饰的 Fe3O4 高效 SDT 用于治疗乳腺癌

IF 2.7 4区材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials Letters Pub Date : 2024-11-23 DOI:10.1016/j.matlet.2024.137721

Xueqi Bai , Shihang Li , Jiayang Yang , Ying Lu , Rong Li , Jianbo Song , Xiudong Guo

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引用次数: 0

摘要

声动力疗法（SDT）是一种非侵入性抗肿瘤策略，具有疗效好、穿透力强、副作用小等特点。然而，肿瘤缺氧和过氧化氢（H2O2）高表达的微环境限制了声动力疗法的效率。在这项工作中，我们采用水热法制备了一种超声增强抗肿瘤材料，并通过控制姜黄素（Fe3O4/Cur）的质量确定了具有最佳催化能力的纳米材料。Fe3O4/Cur不仅能在超声激发下产生ROS，还能与H2O2发生芬顿反应产生ROS，Fe3O4/Cur的SDT效应进一步增强。在超声波刺激下，Fe3O4/Cur 能在 15 分钟内有效杀死乳腺癌细胞。这项研究为乳腺癌的治疗提供了新的思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Curcumin modified Fe3O4 with efficient SDT for the treatment of breast cancer

Sonodynamic therapy (SDT) is a non-invasive anti-tumor strategy with good efficacy, strong penetration and few side effects. However, the microenvironment of tumor hypoxia and high expression of hydrogen peroxide (H₂O₂) limits the efficiency of SDT. In this work, we have prepared a ultrasound-enhanced anti-tumor material by hydrothermal method, and the nanomaterials with optimal catalytic ability are identified by controlling the quality of curcumin (Fe₃O₄/Cur). The Fe₃O₄/Cur is not only capable of generating ROS by ultrasound excitation, but also generates ROS by the Fenton reaction with H₂O₂, and the SDT effect of Fe₃O₄/Cur is further enhanced. Under ultrasound stimulation, the Fe₃O₄/Cur can effectively kill the breast cancer cells within 15 min. This work provides a new idea for the treatment of breast cancer.

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来源期刊

Materials Letters 工程技术-材料科学：综合

CiteScore

5.60

自引率

3.30%

发文量

1948

审稿时长

50 days

期刊介绍： Materials Letters has an open access mirror journal Materials Letters: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Materials Letters is dedicated to publishing novel, cutting edge reports of broad interest to the materials community. The journal provides a forum for materials scientists and engineers, physicists, and chemists to rapidly communicate on the most important topics in the field of materials. Contributions include, but are not limited to, a variety of topics such as: • Materials - Metals and alloys, amorphous solids, ceramics, composites, polymers, semiconductors • Applications - Structural, opto-electronic, magnetic, medical, MEMS, sensors, smart • Characterization - Analytical, microscopy, scanning probes, nanoscopic, optical, electrical, magnetic, acoustic, spectroscopic, diffraction • Novel Materials - Micro and nanostructures (nanowires, nanotubes, nanoparticles), nanocomposites, thin films, superlattices, quantum dots. • Processing - Crystal growth, thin film processing, sol-gel processing, mechanical processing, assembly, nanocrystalline processing. • Properties - Mechanical, magnetic, optical, electrical, ferroelectric, thermal, interfacial, transport, thermodynamic • Synthesis - Quenching, solid state, solidification, solution synthesis, vapor deposition, high pressure, explosive