Jolene A. Giacinti , Madeline Jarvis-Cross , Hannah Lewis , Jennifer F. Provencher , Yohannes Berhane , Kevin Kuchinski , Claire M. Jardine , Anthony Signore , Sarah C. Mansour , Denby E. Sadler , Brian Stevens , Natalie A. Prystajecky , Sailendra N. Sarma , Davor Ojkic , Gabrielle Angelo P. Cortez , Marzieh Kalhor , Ethan Kenmuir , Christopher M. Sharp
{"title":"高致病性禽流感病毒在野生动物-家禽-环境界面的传播动态:案例研究","authors":"Jolene A. Giacinti , Madeline Jarvis-Cross , Hannah Lewis , Jennifer F. Provencher , Yohannes Berhane , Kevin Kuchinski , Claire M. Jardine , Anthony Signore , Sarah C. Mansour , Denby E. Sadler , Brian Stevens , Natalie A. Prystajecky , Sailendra N. Sarma , Davor Ojkic , Gabrielle Angelo P. Cortez , Marzieh Kalhor , Ethan Kenmuir , Christopher M. Sharp","doi":"10.1016/j.onehlt.2024.100932","DOIUrl":null,"url":null,"abstract":"<div><div>Avian influenza viruses (AIVs) regularly circulate between wild and domestic bird populations. Following several high-profile outbreaks, highly pathogenic AIVs (HPAIV) with zoonotic potential have been the subject of increasing attention. While we know that HPAIV is transmitted between domestic birds, wildlife, and the environment, little is known about persistence and spillover/back at these interfaces. We integrated the test results of samples collected on and around an infected domestic poultry premise (IP) where H5N1 HPAIV was confirmed in a flock of poultry in 2022 in Southern Ontario, Canada to explore the transmission cycle of AIVs in wildlife and the environment. We sampled a captive flock of Mallards (<em>Anas platyrhynchos</em>) that resided on site, sediment samples collected from water bodies on site, and examined samples collected through surveillance within a 100 km radius of the IP from live wild ducks and sick and dead wildlife. We found serologic evidence of H5 exposure in the captive mallards that resided on site despite no evidence of morbidity or mortality in these birds and no PCR positive detections from samples collected at two different timepoints. Genetic material from the same H5N1 HPAIV subtype circulating in the domestic birds and from low pathogenicity avian influenza viruses were detected in wetlands on site. The results of live and sick and dead surveillance conducted within a 100 km radius confirmed that the virus was circulating in wildlife before and after IP confirmation. These results suggest that biosecurity remains the most critical aspect of minimising spillover/back risk in a virus that has been shown to circulate in asymptomatic wild birds and persist in the surrounding environment.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"19 ","pages":"Article 100932"},"PeriodicalIF":4.1000,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Transmission dynamics of highly pathogenic avian influenza virus at the wildlife-poultry-environmental interface: A case study\",\"authors\":\"Jolene A. Giacinti , Madeline Jarvis-Cross , Hannah Lewis , Jennifer F. Provencher , Yohannes Berhane , Kevin Kuchinski , Claire M. Jardine , Anthony Signore , Sarah C. Mansour , Denby E. Sadler , Brian Stevens , Natalie A. Prystajecky , Sailendra N. Sarma , Davor Ojkic , Gabrielle Angelo P. Cortez , Marzieh Kalhor , Ethan Kenmuir , Christopher M. Sharp\",\"doi\":\"10.1016/j.onehlt.2024.100932\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Avian influenza viruses (AIVs) regularly circulate between wild and domestic bird populations. Following several high-profile outbreaks, highly pathogenic AIVs (HPAIV) with zoonotic potential have been the subject of increasing attention. While we know that HPAIV is transmitted between domestic birds, wildlife, and the environment, little is known about persistence and spillover/back at these interfaces. We integrated the test results of samples collected on and around an infected domestic poultry premise (IP) where H5N1 HPAIV was confirmed in a flock of poultry in 2022 in Southern Ontario, Canada to explore the transmission cycle of AIVs in wildlife and the environment. We sampled a captive flock of Mallards (<em>Anas platyrhynchos</em>) that resided on site, sediment samples collected from water bodies on site, and examined samples collected through surveillance within a 100 km radius of the IP from live wild ducks and sick and dead wildlife. We found serologic evidence of H5 exposure in the captive mallards that resided on site despite no evidence of morbidity or mortality in these birds and no PCR positive detections from samples collected at two different timepoints. Genetic material from the same H5N1 HPAIV subtype circulating in the domestic birds and from low pathogenicity avian influenza viruses were detected in wetlands on site. The results of live and sick and dead surveillance conducted within a 100 km radius confirmed that the virus was circulating in wildlife before and after IP confirmation. These results suggest that biosecurity remains the most critical aspect of minimising spillover/back risk in a virus that has been shown to circulate in asymptomatic wild birds and persist in the surrounding environment.</div></div>\",\"PeriodicalId\":19577,\"journal\":{\"name\":\"One Health\",\"volume\":\"19 \",\"pages\":\"Article 100932\"},\"PeriodicalIF\":4.1000,\"publicationDate\":\"2024-11-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"One Health\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2352771424002581\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"One Health","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2352771424002581","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0
摘要
禽流感病毒 (AIV) 经常在野生鸟类和家禽之间传播。在几次引人注目的疫情爆发之后,具有人畜共患病潜能的高致病性禽流感病毒(HPAIV)越来越受到关注。虽然我们知道高致病性禽流感病毒会在家禽、野生动物和环境之间传播,但对其在这些界面上的持久性和溢出/回流却知之甚少。2022 年,加拿大安大略省南部的一群家禽被证实感染了 H5N1 高致病性禽流感病毒,我们综合了在受感染的家禽饲养场(IP)及其周围采集的样本的检测结果,以探索禽流感病毒在野生动物和环境中的传播周期。我们在现场对圈养的野鸭群(Anas platyrhynchos)进行了采样,并从现场水体中采集了沉积物样本,同时还检查了通过监测在 IP 100 公里半径范围内从活体野鸭和病死野生动物身上采集的样本。我们在现场饲养的野鸭身上发现了接触 H5 病毒的血清学证据,尽管没有证据表明这些野鸭发病或死亡,而且在两个不同时间点采集的样本中也没有检测到 PCR 阳性结果。在现场的湿地中检测到了在家禽中流行的同一 H5N1 高致病性禽流感病毒亚型和低致病性禽流感病毒的遗传物质。在方圆 100 公里范围内进行的活禽和病死禽监测结果证实,在 IP 确认前后,病毒都在野生动物中流行。这些结果表明,生物安全仍是最大限度降低病毒外溢/回流风险的最关键环节,因为这种病毒已被证明可在无症状的野生鸟类中传播,并在周围环境中持续存在。
Transmission dynamics of highly pathogenic avian influenza virus at the wildlife-poultry-environmental interface: A case study
Avian influenza viruses (AIVs) regularly circulate between wild and domestic bird populations. Following several high-profile outbreaks, highly pathogenic AIVs (HPAIV) with zoonotic potential have been the subject of increasing attention. While we know that HPAIV is transmitted between domestic birds, wildlife, and the environment, little is known about persistence and spillover/back at these interfaces. We integrated the test results of samples collected on and around an infected domestic poultry premise (IP) where H5N1 HPAIV was confirmed in a flock of poultry in 2022 in Southern Ontario, Canada to explore the transmission cycle of AIVs in wildlife and the environment. We sampled a captive flock of Mallards (Anas platyrhynchos) that resided on site, sediment samples collected from water bodies on site, and examined samples collected through surveillance within a 100 km radius of the IP from live wild ducks and sick and dead wildlife. We found serologic evidence of H5 exposure in the captive mallards that resided on site despite no evidence of morbidity or mortality in these birds and no PCR positive detections from samples collected at two different timepoints. Genetic material from the same H5N1 HPAIV subtype circulating in the domestic birds and from low pathogenicity avian influenza viruses were detected in wetlands on site. The results of live and sick and dead surveillance conducted within a 100 km radius confirmed that the virus was circulating in wildlife before and after IP confirmation. These results suggest that biosecurity remains the most critical aspect of minimising spillover/back risk in a virus that has been shown to circulate in asymptomatic wild birds and persist in the surrounding environment.
期刊介绍:
One Health - a Gold Open Access journal.
The mission of One Health is to provide a platform for rapid communication of high quality scientific knowledge on inter- and intra-species pathogen transmission, bringing together leading experts in virology, bacteriology, parasitology, mycology, vectors and vector-borne diseases, tropical health, veterinary sciences, pathology, immunology, food safety, mathematical modelling, epidemiology, public health research and emergency preparedness. As a Gold Open Access journal, a fee is payable on acceptance of the paper. Please see the Guide for Authors for more information.
Submissions to the following categories are welcome:
Virology,
Bacteriology,
Parasitology,
Mycology,
Vectors and vector-borne diseases,
Co-infections and co-morbidities,
Disease spatial surveillance,
Modelling,
Tropical Health,
Discovery,
Ecosystem Health,
Public Health.