人格障碍成人中 5-HTT、COMT 和 BDNF 功能多态性及其与父母亲情在依恋焦虑中的相互作用的影响

IF 2.5 4区医学 Q2 PSYCHIATRY

European Journal of Psychiatry Pub Date : 2024-11-18 DOI:10.1016/j.ejpsy.2024.100270

Leire Erkoreka , Iker Zamalloa , Pedro Muñoz , Santiago Rodriguez , Aurora Arrue , Miguel Angel Gonzalez-Torres

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引用次数: 0

摘要

背景和目的依恋是人类对特定人物产生强烈情感纽带的倾向，被描述为导致各种形式精神病理学的普遍易感因素。尽管依恋研究并不倾向于强调遗传因素，但其遗传率估计为 36-45%。我们探讨了 5-HTTLPR、COMT Val158Met 和 BDNF Val66Met 功能多态性与依恋维度之间的关系，以及基因与环境之间的相互作用，同时考虑了感知到的父母养育方式，采用了易感性和差异易感性两种方法。研究使用《亲密关系经历-修订版》对依恋进行评估，并使用《父母关系工具》对养育方式进行评估。基因型通过唾液样本进行分析。结果COMT ValVal同源基因携带者和BDNF Met基因携带者的依恋焦虑得分明显更高（COMT：ValVal 4.95±1.25 vs Met-carriers 4.42±1.30，t=-2.096，p=0.038；BDNF：ValVal 4.38±1.31 vs Met-carriers 4.95±1.24，t=2.833，p=0.005）。通过差异易感性方法，确定了三种功能性多态性的可塑性基因型，观察到与父母过度保护的显著交互作用，以及与依恋焦虑有关的差异结果。结论我们的研究结果表明，就成人依恋结果而言，有些个体更容易受到抚养经历的影响，这可能也意味着他们更有可能从环境和心理治疗干预中受益。

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Influence of 5-HTT, COMT, and BDNF functional polymorphisms and their interaction with parental bonding in attachment anxiety, among adults with personality disorders

Background and objectives

Attachment is the tendency of human beings to create strong affective bonds towards specific figures, and has been described as a general vulnerability factor to diverse forms of psychopathology. Although attachment research has not tended to emphasize genetic contribution, heritability is estimated at 36–45 %. We explored the association between 5-HTTLPR, COMT Val158Met and BDNF Val66Met functional polymorphisms with attachment dimensions, as well as the gene-environment interaction, considering the perceived parental rearing styles, with both a vulnerability and a differential susceptibility approach.

Methods

150 outpatients with a cluster B personality disorder participated in the study. Attachment was assessed using Experiences in Close Relationships-Revised and rearing styles by means of the Parental Bonding Instrument. Genotypes were analyzed using saliva samples. Statistical analyses were carried out with general linear models.

Results

COMT ValVal homozygotes and BDNF Met-carriers were associated with significantly higher scores in attachment anxiety (COMT: ValVal 4.95±1.25 vs Met-carriers 4.42±1.30, t=-2.096, p=0.038; BDNF: ValVal 4.38±1.31 vs Met-carriers 4.95±1.24, t = 2.833, p=0.005). From a differential susceptibility approach, plasticity genotypes were identified for the three functional polymorphisms, observing significant interactions with parental overprotection and differential outcomes in relation to attachment anxiety. No associations or interactions were found with regard to attachment avoidance and the care dimension.

Conclusion

Our results suggest that there are individuals more susceptible to rearing experiences in terms of adult attachment outcomes, which probably also implies a greater potential to benefit from environmental and psychotherapeutic interventions.

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来源期刊

European Journal of Psychiatry PSYCHIATRY-

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

43 days

期刊介绍： The European journal of psychiatry is a quarterly publication founded in 1986 and directed by Professor Seva until his death in 2004. It was originally intended to report “the scientific activity of European psychiatrists” and “to bring about a greater degree of communication” among them. However, “since scientific knowledge has no geographical or cultural boundaries, is open to contributions from all over the world”. These principles are maintained in the new stage of the journal, now expanded with the help of an American editor.