辣椒素水提取物的综合评价：评估其在体外和体内对肠道屏障完整性和炎症的影响

IF 3.8 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods Pub Date : 2024-11-20 DOI:10.1016/j.jff.2024.106563

Yu Rim Kim, Soo-yeon Park, Ji Yeon Kim

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引用次数: 0

摘要

Capsosiphon fulvescens 具有潜在的功能性益处。然而，有关其对肠道健康影响的研究还很有限。本研究调查了 Capsosiphon fulvescens 水提取物（CFW）的治疗功效，并在 Caco-2 细胞和小鼠模型中证实了其对肠道健康的益处。在动物实验中，32 只雄性 C57BL/6 小鼠被分为对照组、DSS 组和 CFW 治疗组，连续治疗 28 天，其中 DSS 在 7 天内自由饮用。在体外模型中观察到，与肠道屏障功能有关的各种生物标志物均有明显改善，包括经上皮电阻值增加和渗透性降低。此外，服用 CFW 还改善了组织学评分，提高了 TJ 蛋白和细胞因子的水平。据信，CFW 的治疗功效与提取物中的生物活性化合物有关。本文的研究结果凸显了 CFW 在治疗炎症性肠病方面的巨大潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Comprehensive evaluation of Capsosiphon fulvescens water extract: Assessing its effects on intestinal barrier integrity and inflammation in vitro and in vivo

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Comprehensive evaluation of Capsosiphon fulvescens water extract: Assessing its effects on intestinal barrier integrity and inflammation in vitro and in vivo

Capsosiphon fulvescens has potential benefits for functionality. However, research on its impact on gut health is limited. In this study, the therapeutic efficacy of Capsosiphon fulvescens water extract (CFW) was investigated, with its intestinal health benefits confirmed in Caco-2 cell and mouse models. In the animal study, 32 male C57BL/6 mice were divided into control, DSS, and CFW treatment groups and treated for 28 days, with DSS given ad libitum in 7 days. Significant improvements in various biomarkers related to intestinal barrier function, including increased transepithelial electrical resistance values and reduced permeability, were observed in vitro model. Moreover, the administration of CFW was associated with improved histological scores and improved levels of TJ proteins and cytokines. The therapeutic efficacy of CFW is believed to be associated with the bioactive compounds found in the extract. The findings here highlight the promising therapeutic potential of CFW for managing inflammatory bowel disease.

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来源期刊

Journal of Functional Foods FOOD SCIENCE & TECHNOLOGY-

CiteScore

9.60

自引率

1.80%

发文量

428

审稿时长

76 days

期刊介绍： Journal of Functional Foods continues with the same aims and scope, editorial team, submission system and rigorous peer review. We give authors the possibility to publish their top-quality papers in a well-established leading journal in the food and nutrition fields. The Journal will keep its rigorous criteria to screen high impact research addressing relevant scientific topics and performed by sound methodologies. The Journal of Functional Foods aims to bring together the results of fundamental and applied research into healthy foods and biologically active food ingredients. The Journal is centered in the specific area at the boundaries among food technology, nutrition and health welcoming papers having a good interdisciplinary approach. The Journal will cover the fields of plant bioactives; dietary fibre, probiotics; functional lipids; bioactive peptides; vitamins, minerals and botanicals and other dietary supplements. Nutritional and technological aspects related to the development of functional foods and beverages are of core interest to the journal. Experimental works dealing with food digestion, bioavailability of food bioactives and on the mechanisms by which foods and their components are able to modulate physiological parameters connected with disease prevention are of particular interest as well as those dealing with personalized nutrition and nutritional needs in pathological subjects.