副酸乳杆菌 FZJJH2L6 通过丙酸-5-HT-ACh 途径减轻阴性结肠炎的症状

IF 3.8 2区 农林科学 Q2 FOOD SCIENCE & TECHNOLOGY
Mengxia Liang , Huimin Lu , Shengnan Zhu , Liping Cao , Zhichao Yang , Linlin Wang , Jianxin Zhao
{"title":"副酸乳杆菌 FZJJH2L6 通过丙酸-5-HT-ACh 途径减轻阴性结肠炎的症状","authors":"Mengxia Liang ,&nbsp;Huimin Lu ,&nbsp;Shengnan Zhu ,&nbsp;Liping Cao ,&nbsp;Zhichao Yang ,&nbsp;Linlin Wang ,&nbsp;Jianxin Zhao","doi":"10.1016/j.jff.2024.106585","DOIUrl":null,"url":null,"abstract":"<div><div>Cathartic colon (CC), a form of constipation induced by the chronic abuse and dependence on stimulant laxatives. The application of probiotics to alleviate related diseases has become the research hotspot. In this study, a CC model was constructed by intragastric administration of senna extract, and <em>Lactobacillus paracasei</em> CCFM1164 was used as a positive control to screen strains that can alleviate this constipation. The findings indicate that <em>Lactobacillus paracasei</em> FZJJH2L6 effectively mitigates cathartic colon. The potential mechanisms were explored from the perspectives of enteric nerve repair and intestinal barrier restoration. Results demonstrated that <em>Lactobacillus paracasei</em> FZJJH2L6 increased the content of propionic acid in feces by increasing the relative abundance of short-chain fatty acids-producing bacteria. This upregulated acetylcholine and 5-hydroxytryptamine levels in the colon, reduced intestinal inflammation, repaired the intestinal mechanical barrier, and ultimately alleviated CC. This study provides a theoretical basis for the use of probiotics in alleviating cathartic colon.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"123 ","pages":"Article 106585"},"PeriodicalIF":3.8000,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Lactobacillus paracasei FZJJH2L6 alleviates cathartic Colon via the propionic Acid-5-HT-ACh pathway\",\"authors\":\"Mengxia Liang ,&nbsp;Huimin Lu ,&nbsp;Shengnan Zhu ,&nbsp;Liping Cao ,&nbsp;Zhichao Yang ,&nbsp;Linlin Wang ,&nbsp;Jianxin Zhao\",\"doi\":\"10.1016/j.jff.2024.106585\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Cathartic colon (CC), a form of constipation induced by the chronic abuse and dependence on stimulant laxatives. The application of probiotics to alleviate related diseases has become the research hotspot. In this study, a CC model was constructed by intragastric administration of senna extract, and <em>Lactobacillus paracasei</em> CCFM1164 was used as a positive control to screen strains that can alleviate this constipation. The findings indicate that <em>Lactobacillus paracasei</em> FZJJH2L6 effectively mitigates cathartic colon. The potential mechanisms were explored from the perspectives of enteric nerve repair and intestinal barrier restoration. Results demonstrated that <em>Lactobacillus paracasei</em> FZJJH2L6 increased the content of propionic acid in feces by increasing the relative abundance of short-chain fatty acids-producing bacteria. This upregulated acetylcholine and 5-hydroxytryptamine levels in the colon, reduced intestinal inflammation, repaired the intestinal mechanical barrier, and ultimately alleviated CC. This study provides a theoretical basis for the use of probiotics in alleviating cathartic colon.</div></div>\",\"PeriodicalId\":360,\"journal\":{\"name\":\"Journal of Functional Foods\",\"volume\":\"123 \",\"pages\":\"Article 106585\"},\"PeriodicalIF\":3.8000,\"publicationDate\":\"2024-11-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Functional Foods\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1756464624005887\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"FOOD SCIENCE & TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Functional Foods","FirstCategoryId":"97","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1756464624005887","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

阴性结肠(CC),是一种因长期滥用和依赖刺激性泻药而诱发的便秘。应用益生菌缓解相关疾病已成为研究热点。本研究通过番泻叶提取物的胃内给药构建了CC模型,并以副卡西氏乳杆菌CCFM1164作为阳性对照,筛选能缓解这种便秘的菌株。研究结果表明,副酸乳杆菌 FZJJH2L6 能有效缓解阴性结肠炎。研究人员从肠道神经修复和肠道屏障恢复的角度探讨了其潜在机制。结果表明,副卡氏乳杆菌 FZJJH2L6 通过增加短链脂肪酸产生菌的相对丰度来增加粪便中丙酸的含量。这提高了结肠中乙酰胆碱和 5-羟色胺的水平,减轻了肠道炎症,修复了肠道机械屏障,最终缓解了 CC。这项研究为使用益生菌缓解阴性结肠炎提供了理论依据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Lactobacillus paracasei FZJJH2L6 alleviates cathartic Colon via the propionic Acid-5-HT-ACh pathway

Lactobacillus paracasei FZJJH2L6 alleviates cathartic Colon via the propionic Acid-5-HT-ACh pathway
Cathartic colon (CC), a form of constipation induced by the chronic abuse and dependence on stimulant laxatives. The application of probiotics to alleviate related diseases has become the research hotspot. In this study, a CC model was constructed by intragastric administration of senna extract, and Lactobacillus paracasei CCFM1164 was used as a positive control to screen strains that can alleviate this constipation. The findings indicate that Lactobacillus paracasei FZJJH2L6 effectively mitigates cathartic colon. The potential mechanisms were explored from the perspectives of enteric nerve repair and intestinal barrier restoration. Results demonstrated that Lactobacillus paracasei FZJJH2L6 increased the content of propionic acid in feces by increasing the relative abundance of short-chain fatty acids-producing bacteria. This upregulated acetylcholine and 5-hydroxytryptamine levels in the colon, reduced intestinal inflammation, repaired the intestinal mechanical barrier, and ultimately alleviated CC. This study provides a theoretical basis for the use of probiotics in alleviating cathartic colon.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Journal of Functional Foods
Journal of Functional Foods FOOD SCIENCE & TECHNOLOGY-
CiteScore
9.60
自引率
1.80%
发文量
428
审稿时长
76 days
期刊介绍: Journal of Functional Foods continues with the same aims and scope, editorial team, submission system and rigorous peer review. We give authors the possibility to publish their top-quality papers in a well-established leading journal in the food and nutrition fields. The Journal will keep its rigorous criteria to screen high impact research addressing relevant scientific topics and performed by sound methodologies. The Journal of Functional Foods aims to bring together the results of fundamental and applied research into healthy foods and biologically active food ingredients. The Journal is centered in the specific area at the boundaries among food technology, nutrition and health welcoming papers having a good interdisciplinary approach. The Journal will cover the fields of plant bioactives; dietary fibre, probiotics; functional lipids; bioactive peptides; vitamins, minerals and botanicals and other dietary supplements. Nutritional and technological aspects related to the development of functional foods and beverages are of core interest to the journal. Experimental works dealing with food digestion, bioavailability of food bioactives and on the mechanisms by which foods and their components are able to modulate physiological parameters connected with disease prevention are of particular interest as well as those dealing with personalized nutrition and nutritional needs in pathological subjects.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信