眼科近距离放射治疗 Ru-106 斑块验收测试新设备的临床评估

IF 1.6 3区物理与天体物理 Q2 NUCLEAR SCIENCE & TECHNOLOGY

Radiation Measurements Pub Date : 2024-11-17 DOI:10.1016/j.radmeas.2024.107343

María Martorell Ruiz , Roberto M. Sánchez Casanueva , Antonio Gañán Mora , José M. Fernández-Soto

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引用次数: 0

摘要

目的眼科近距离放射治疗通过在巩膜上缝合含有放射性核素（如 Ru-106）的斑块来治疗眼部病变。符合质量保证标准至关重要，但实际操作的局限性使临床实践中的独立源强度测量变得复杂。方法和材料为 Ru-106 斑块评估而设计的系统包括一个可注水的幻影盆、一个与电子计相连的电子二极管、根据斑块类型而定的支架和一个微米计。测试包括由六位医学物理专家和学员对三种斑块类型（CCA、CIB、COB）进行测量，评估观察者之间和观察者内部的可变性，以及在参考点（2 毫米）进行测量的适用性。观察者内部和观察者之间的变异性极小（分别为测量值的 1.0% 和 1.3%），证实了系统在操作者影响方面的稳健性。结论该系统适用于 Ru-106 斑块验收测试，可确保在 2 毫米处对斑块进行准确定位和剂量率验证。这些结果证实了该系统作为符合质量保证标准的支持系统的潜力。这些结果有待颁发相应的 Si-diode 校准证书。

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Clinical evaluation of a new device for acceptance testing of Ru-106 plaques in ophthalmic brachytherapy

Purpose

Ophthalmic brachytherapy treats eye lesions by stitching plaques containing a radionuclide (e.g. Ru-106) onto the sclera. Compliance with quality assurance standards is crucial, but practical limitations complicate independent source strength measurement in clinical practice. In this article, a new prototype for acceptance testing of Ru-106 plaques is assayed to assess its suitability for a hospital's medical physics department.

Methods and materials

The system designed for Ru-106 plaque assessment includes a phantom basin fillable with water, a Si-diode for electrons coupled with an electrometer, type-dependent plaque holders and a micrometre gauge. Testing involved the measurement of three plaque types (CCA, CIB, COB) by six medical physics experts and trainees, the assessment of inter and intra-observer variability and the suitability for measurement at the reference point, 2 mm.

Results

Measured absorbed dose rates in water at 2 mm from the plaque surface demonstrated compatibility across all testers for the three plaques. Intra and inter-observer variability was minimal (1.0% and 1.3% of the measured value, respectively), confirming system robustness in terms of operator influence.

Conclusions

The system proves suitable for Ru-106 plaque acceptance testing ensuring accurate plaque positioning and dose rate verification at 2 mm. These findings confirm its potential as a support for compliance with quality assurance standards. These results are subject to the issue of the corresponding calibration certificate for the Si-diode.

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来源期刊

Radiation Measurements 工程技术-核科学技术

CiteScore

4.10

自引率

20.00%

发文量

116

审稿时长

48 days

期刊介绍： The journal seeks to publish papers that present advances in the following areas: spontaneous and stimulated luminescence (including scintillating materials, thermoluminescence, and optically stimulated luminescence); electron spin resonance of natural and synthetic materials; the physics, design and performance of radiation measurements (including computational modelling such as electronic transport simulations); the novel basic aspects of radiation measurement in medical physics. Studies of energy-transfer phenomena, track physics and microdosimetry are also of interest to the journal. Applications relevant to the journal, particularly where they present novel detection techniques, novel analytical approaches or novel materials, include: personal dosimetry (including dosimetric quantities, active/electronic and passive monitoring techniques for photon, neutron and charged-particle exposures); environmental dosimetry (including methodological advances and predictive models related to radon, but generally excluding local survey results of radon where the main aim is to establish the radiation risk to populations); cosmic and high-energy radiation measurements (including dosimetry, space radiation effects, and single event upsets); dosimetry-based archaeological and Quaternary dating; dosimetry-based approaches to thermochronometry; accident and retrospective dosimetry (including activation detectors), and dosimetry and measurements related to medical applications.