利用多通道 TMS 探究初级运动皮层兴奋和抑制回路的方向特异性

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology Pub Date : 2024-11-16 DOI:10.1016/j.clinph.2024.11.004

Victor H. Souza , Jaakko O. Nieminen , Sergei Tugin , Lari M. Koponen , Ulf Ziemann , Oswaldo Baffa , Risto J. Ilmoniemi

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引用次数: 0

摘要

目的电场方向对于优化经颅磁刺激（TMS）的神经元兴奋至关重要。然而，由于在几毫秒内操纵 TMS 引起的刺激方向的技术难题，人们对刺激方向对短间隔皮层内抑制（SICI）和皮层内促进（ICF）的影响知之甚少。我们旨在评估 SICI 和 ICF 范式的方向敏感性，并确定运动诱发电位（MEP）促进和抑制的最佳方向。结果 MEP 调制受条件刺激和测试刺激方向的影响，当两个脉冲方向相同时调制最强。结论SICI和ICF的方向敏感性对条件刺激方向表现出复杂的依赖性，这可能是抑制性和兴奋性神经元群的解剖学和形态学排列造成的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Probing the orientation specificity of excitatory and inhibitory circuitries in the primary motor cortex with multi-channel TMS

查看原文本刊更多论文

Probing the orientation specificity of excitatory and inhibitory circuitries in the primary motor cortex with multi-channel TMS

Objective

Electric-field orientation is crucial for optimizing neuronal excitation in transcranial magnetic stimulation (TMS). Yet, the stimulus orientation effects on short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF) are poorly understood due to technical challenges in manipulating the TMS-induced stimulus orientation within milliseconds. We aimed to assess the orientation sensitivity of SICI and ICF paradigms and identify optimal orientations for motor evoked potential (MEP) facilitation and suppression.

Methods

We applied paired-pulse multi-channel TMS to 12 healthy subjects with conditioning and test stimuli in the same, opposite, and perpendicular orientations to each other at four interstimulus intervals (ISI) to generate refractoriness, SICI, and ICF.

Results

MEP modulation was affected by the conditioning- and test-stimulus orientation, being strongest when both pulses were in the same direction. MEP modulation with 2.5-ms and 6.0-ms ISIs were more sensitive to orientation changes than 0.5- and 8.0-ms ISIs.

Conclusion

SICI and ICF orientation sensitivity exhibit a complex dependence on the conditioning stimulus orientation, which might be explained by anatomical and morphological arrangements of inhibitory and excitatory neuronal populations.

Significance

Distinct mechanisms mediating SICI and ICF are sensitive to stimulus orientation at specific ISIs, describing a structural–functional relationship that maximizes each effect at the cortical level.

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.