用于有丝分裂过程中多种分析物的单/双/多反应荧光探针：综述

IF 4.1 3区工程技术 Q2 CHEMISTRY, APPLIED

Dyes and Pigments Pub Date : 2024-11-18 DOI:10.1016/j.dyepig.2024.112545

Sha Li, Zhiying Li, Miao Yan, Haixian Ren

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引用次数: 0

摘要

作为细胞的 "发电站"，线粒体参与了许多能量代谢过程。线粒体结构和功能异常（线粒体吞噬）会影响活细胞的活动并导致疾病。要更好地了解线粒体吞噬过程的可视化，就必须对相关分析物的浓度变化进行实时可视化。据报道，有几种探针可用于检测线粒体中的一种或多种分析物。但是，还没有对这一主题进行总结。因此，探索小分子荧光探针在这一新兴领域的最新进展非常重要。基于分析物在线粒体自噬中的作用，本文回顾了自2016年以来，具有特异性识别功能和线粒体自噬相关分析物（包括pH、粘度、极性、缺氧和线粒体ROS RSS波动）选择性信号转换的单/双/多响应荧光探针的最新进展。我们相信，这篇综述将引起从事线粒体自噬相关研究的科学家的广泛兴趣，并为化学家、生物学家和医学研究人员提供有价值的见解，为相关疾病的诊断和治疗做出贡献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Single/dual/multi-responsive fluorescent probes for multiple analytes in mitophagy: A review

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Single/dual/multi-responsive fluorescent probes for multiple analytes in mitophagy: A review

As the "power stations" of the cell, mitochondria are involved in many energy metabolism processes. Abnormalities in mitochondrial structure and function (mitophagy) can affect the activity of living cells and lead to disease. Visualizing the concentration changes in the relevant analytes in real time is essential to better understand the visualization of mitophagy processes. Several probes have been reported for the detection of one or more analytes in mitochondria. However, topic has not been summarized. Therefore, it is very important to explore the latest progress of small molecule fluorescent probes in this emerging field. Based on the role of analytes in mitochondrial autophagy, this reviews recent advances in single/double/multi-responsive fluorescent probes with specific recognition function and selective signal conversion of mitochondrial autophagy related analytes (including pH, viscosity, polarity, hypoxia, and mitochondrial ROS RSS fluctuations) since 2016. We believe that this review will be of wide interest to scientists engaged in research related to mitochondrial autophagy and provide valuable insights to chemists, biologists and medical researchers to contribute to the diagnosis and treatment of related diseases.

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来源期刊

Dyes and Pigments 工程技术-材料科学：纺织

CiteScore

8.20

自引率

13.30%

发文量

933

审稿时长

33 days

期刊介绍： Dyes and Pigments covers the scientific and technical aspects of the chemistry and physics of dyes, pigments and their intermediates. Emphasis is placed on the properties of the colouring matters themselves rather than on their applications or the system in which they may be applied. Thus the journal accepts research and review papers on the synthesis of dyes, pigments and intermediates, their physical or chemical properties, e.g. spectroscopic, surface, solution or solid state characteristics, the physical aspects of their preparation, e.g. precipitation, nucleation and growth, crystal formation, liquid crystalline characteristics, their photochemical, ecological or biological properties and the relationship between colour and chemical constitution. However, papers are considered which deal with the more fundamental aspects of colourant application and of the interactions of colourants with substrates or media. The journal will interest a wide variety of workers in a range of disciplines whose work involves dyes, pigments and their intermediates, and provides a platform for investigators with common interests but diverse fields of activity such as cosmetics, reprographics, dye and pigment synthesis, medical research, polymers, etc.