Mohamed N. Zedan , Mai E. Shoman , Mohamed Abdel-Aziz , Hamdy M. Abdel-Rahman
{"title":"1,2,4-三唑并[1,5-a]嘧啶最常用的合成途径概述","authors":"Mohamed N. Zedan , Mai E. Shoman , Mohamed Abdel-Aziz , Hamdy M. Abdel-Rahman","doi":"10.1016/j.rechem.2024.101903","DOIUrl":null,"url":null,"abstract":"<div><div>Among the all possible isomers of triazolopyrimidines, 1,2,4-triazolo[1,5-<em>a</em>]pyrimidines are the most important isomers owing to their vast activities in agriculture and medicinal chemistry. Herein, we present an overview of the most used synthetic pathways of this scaffold to assist researchers design new drug molecules with expected pharmacological activities</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"12 ","pages":"Article 101903"},"PeriodicalIF":2.5000,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"An overview of the most used synthetic pathways of 1,2,4-triazolo[1,5-a]pyrimidines\",\"authors\":\"Mohamed N. Zedan , Mai E. Shoman , Mohamed Abdel-Aziz , Hamdy M. Abdel-Rahman\",\"doi\":\"10.1016/j.rechem.2024.101903\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Among the all possible isomers of triazolopyrimidines, 1,2,4-triazolo[1,5-<em>a</em>]pyrimidines are the most important isomers owing to their vast activities in agriculture and medicinal chemistry. Herein, we present an overview of the most used synthetic pathways of this scaffold to assist researchers design new drug molecules with expected pharmacological activities</div></div>\",\"PeriodicalId\":420,\"journal\":{\"name\":\"Results in Chemistry\",\"volume\":\"12 \",\"pages\":\"Article 101903\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2024-11-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Results in Chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S221171562400599X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Results in Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S221171562400599X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
An overview of the most used synthetic pathways of 1,2,4-triazolo[1,5-a]pyrimidines
Among the all possible isomers of triazolopyrimidines, 1,2,4-triazolo[1,5-a]pyrimidines are the most important isomers owing to their vast activities in agriculture and medicinal chemistry. Herein, we present an overview of the most used synthetic pathways of this scaffold to assist researchers design new drug molecules with expected pharmacological activities