环境臭氧及其与环境 PM2.5 和温度的相互作用对成人哮喘患者呼气流量峰值的影响

IF 4.2 2区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Atmospheric Environment Pub Date : 2024-11-16 DOI:10.1016/j.atmosenv.2024.120939

Dongxia Jiang , Ying Shang , Zhengxiong Li , Xianlin Mu , Xuehu Han , Xinzhuo Xie , Guanglong Fu , Yunshu Zhang , Shaodan Huang , Chun Chang

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引用次数: 0

摘要

大量研究表明，空气污染与哮喘有关。然而，有关环境臭氧（O3）或其与细颗粒物（PM2.5）或温度的相互作用对成人哮喘患者呼气流量峰值（PEF）的影响的信息却很有限。我们进行了一项纵向研究，研究对象包括 99 名成人哮喘患者，记录了 7153 人天的 PEF。利用线性混合效应和分布式非线性模型，我们研究了滞后 0-14 天的环境 O3 暴露与早晚 PEF 之间的关系，以及 PEF 的昼夜变化。研究结果表明，暴露于环境中的臭氧与早晚血压下降之间存在明显的联系，不同滞后天数的暴露量之间存在不同的联系。具体来说，滞后 4 天的暴露量与早晨 PEF 的关系最为明显，每增加 10 μg/m3 的变化为-0.211（95%CI：-0.360，-0.062）升/分钟；对于晚间 PEF，滞后 0 天的暴露量与之关系最为密切，每增加 10 μg/m3 的变化为-0.379（95%CI：-0.721，-0.037）升/分钟。然而，我们没有发现臭氧与昼夜肺活量变异性之间有明显的关联。此外，我们还观察到，从滞后期6到滞后期9，O3和PM2.5暴露对早晨和傍晚的PEF有明显的交互作用；从滞后期1到滞后期11，O3和温度对早晨的PEF有明显的交互作用；从滞后期0到滞后期11，O3和温度对傍晚的PEF有明显的交互作用。在男性、40 岁以上者、超重者、吸烟者和非过敏性哮喘患者中，观察到 O3 与 PEF 之间的关联性更强。这些结果表明，在哮喘管理和支持政策中应考虑污染和气候的综合影响。

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Effect of ambient ozone and its interactions with ambient PM2.5 and temperature on peak expiratory flow in adults with asthma

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Effect of ambient ozone and its interactions with ambient PM2.5 and temperature on peak expiratory flow in adults with asthma

Numerous studies have linked air pollution to asthma. However, limited information exists on the effect of ambient ozone (O₃), or its interactions with fine particulate matter (PM_2.5) or temperature on peak expiratory flow (PEF) of in asthmatic adults. We conducted a longitudinal study including 99 adult asthma patients and documenting 7153 person-days PEF records. Utilizing linear mixed-effect and distributed non-linear models, we investigated the associations between ambient O₃ exposures over lag0-14 days with morning and evening PEF, as well as diurnal PEF variability. Findings revealed significant associations between ambient O₃ exposure with reduced morning and evening PEF, with varied associations for exposures across different lag days. Specifically, the most pronounced association with morning PEF was found for exposure at lag4, with a change of −0.211 (95%CI: −0.360, −0.062) L/min per 10 μg/m³ increase; for evening PEF, the strongest association was observed for exposure at lag0, with a change of −0.379 (95%CI: −0.721, −0.037) L/min per 10 μg/m³ increase. However, no significant association between O₃ and diurnal PEF variability was found. Furthermore, we observed significant interactions between O₃ and PM_2.5 exposures from lag6 to lag9 on morning and evening PEF, and significant interactions between O₃ and temperature from lag1 to lag11 on morning PEF and from lag0 to lag11 on evening PEF. Stronger associations between O₃ and PEF were observed in males, those aged over 40 years, overweight individuals, smokers and those with non-allergic asthma. These results underscore considering combined pollution and climate impacts in asthma management and supporting policies.

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来源期刊

Atmospheric Environment 环境科学-环境科学

CiteScore

9.40

自引率

8.00%

发文量

458

审稿时长

53 days

期刊介绍： Atmospheric Environment has an open access mirror journal Atmospheric Environment: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Atmospheric Environment is the international journal for scientists in different disciplines related to atmospheric composition and its impacts. The journal publishes scientific articles with atmospheric relevance of emissions and depositions of gaseous and particulate compounds, chemical processes and physical effects in the atmosphere, as well as impacts of the changing atmospheric composition on human health, air quality, climate change, and ecosystems.