可见光诱导三组分二氟甲基化环化羧基硫代酯化生成含 CF2 的 γ-内酰胺

IF 3.9 2区化学 Q2 CHEMISTRY, PHYSICAL

Molecular Catalysis Pub Date : 2024-11-21 DOI:10.1016/j.mcat.2024.114685

Dan Shao , Tingting Yu , Lianglong Sun , Zongfei Sun , Xiaorui Zhou , Chunyang Liu , Xuebo Chen , Xin Wang , Kai Sun

引用次数: 0

摘要

本文介绍了一种简便的可见光诱导光催化级联二氟甲基化溴二氟乙酰胺环化反应及随后的羧基硫代酯化反应。该方法可以在温和的条件下高效地获得各种有价值的含 CF2 的 γ-内酰胺，产率从中等到极好。详细的机理研究表明，催化循环中涉及到自由基途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Visible-light-induced three component difluoromethylation cyclization carbo-thioesterification to CF2-Containing γ-Lactams

A facile visible-light-induced photocatalytic cascade difluoromethylation cyclization of bromodifluoroacetamides and subsequent carbo-thioesterification is described. This protocol allows efficient access to a variety of valuable CF₂-containing γ-lactams in moderate to excellent yields under mild conditions. Detailed mechanism study suggest that a radical pathway is involved in the catalytic cycle.

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来源期刊

Molecular Catalysis Chemical Engineering-Process Chemistry and Technology

CiteScore

6.90

自引率

10.90%

发文量

700

审稿时长

40 days

期刊介绍： Molecular Catalysis publishes full papers that are original, rigorous, and scholarly contributions examining the molecular and atomic aspects of catalytic activation and reaction mechanisms. The fields covered are: Heterogeneous catalysis including immobilized molecular catalysts Homogeneous catalysis including organocatalysis, organometallic catalysis and biocatalysis Photo- and electrochemistry Theoretical aspects of catalysis analyzed by computational methods