SARS-CoV-2 使小鼠肺泡巨噬细胞重编程，从而抑制流感。

IF 13.1 1区医学 Q1 IMMUNOLOGY

Trends in Immunology Pub Date : 2024-11-22 DOI:10.1016/j.it.2024.11.002

Alexandra Tabachnikova, Akiko Iwasaki

引用次数: 0

摘要

先天免疫细胞因感染而发生表观遗传重编程，可改变宿主对后续感染的反应。Lercher 等人发现，小鼠气道驻留巨噬细胞在从 SARS-CoV-2 感染中恢复后进行了表观遗传学重编程，从而在甲型流感病毒（IAV）的二次挑战中免于病理变化和致死，而病毒滴度却没有降低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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SARS-CoV-2 reprograms murine alveolar macrophages to dampen flu.

Innate immune cells that are epigenetically reprogrammed by infection can modify host responses to subsequent infections. Lercher et al. have identified epigenetic reprogramming of murine airway-resident macrophages following recovery from SARS-CoV-2 infection, conferring protection from pathology and lethality following secondary influenza A virus (IAV) challenge without reducing viral titers.

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来源期刊

Trends in Immunology 医学-免疫学

CiteScore

25.10

自引率

0.60%

发文量

130

审稿时长

6-12 weeks

期刊介绍： Trends in Immunology serves as a vital platform for tracking advancements across various areas of immunology, offering concise reviews and hypothesis-driven viewpoints in each issue. With additional sections providing comprehensive coverage, the journal offers a holistic view of immunology. This broad perspective makes it an invaluable resource for researchers, educators, and students, facilitating the connection between basic and clinical immunology. Recognized as one of the top monthly review journals in its field, Trends in Immunology is highly regarded by the scientific community.