长期慢性接触空气中的二恶英与乳腺癌之间的关系。

IF 4.5 2区 医学 Q1 INFECTIOUS DISEASES
Delphine Praud , Amina Amadou , Thomas Coudon , Margaux Duboeuf , Benoît Mercoeur , Elodie Faure , Lény Grassot , Aurélie MN. Danjou , Pietro Salizzoni , Florian Couvidat , Laure Dossus , Gianluca Severi , Francesca Romana Mancini , Béatrice Fervers
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引用次数: 0

摘要

乳腺癌是女性最常见的癌症类型。环境污染物,特别是二恶英等具有干扰内分泌特性的污染物,可能会影响乳腺癌的发病。目前关于二恶英暴露与乳腺癌风险之间关系的流行病学研究结果并不一致。为了解决这些不确定性,我们的目标是调查空气中二恶英暴露对 E3N 队列中乳腺癌风险的影响,该队列包括 1990-2011 年间发现的 5222 例病例和 5222 例匹配对照。我们使用基于地理信息系统的指标来评估空气中二恶英的暴露情况,该指标考虑了住宅与二恶英排放源的距离、二恶英排放源的技术特征、暴露持续时间和风向。此外,还利用化学迁移模型 CHIMERE 估算的二恶英浓度进行了其他分析。结果表明,居住地址的累积二恶英暴露量与总体乳腺癌风险之间的风险略有增加(调整后的几率比(OR)= 1.03,95% 置信区间(CI):0.99-1.07,对照组中一个标准差(14.47 log-μg-TEQ/m2 )的增量)。对于 3、5 和 10 千米范围内的污染源,以及将接触范围限制在生活垃圾焚烧炉排放的二恶英时,相关性保持一致。使用 CHIMERE 模型也得出了类似的 OR 估计值(OR = 1.02,95% CI:0.97-1.07,增量为 1 SD)。这项研究结果表明,长期在住宅中接触二恶英可能会增加罹患乳腺癌的风险,并强调了努力减少空气污染接触的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association between chronic long-term exposure to airborne dioxins and breast cancer
Breast cancer is the most common type of cancer among women. Environmental pollutants, specifically those with endocrine disrupting properties like dioxins, may impact breast cancer development. Current epidemiological studies on the association between exposure to dioxins and the risk of breast cancer show inconsistent results. To address these uncertainties, our objective was to investigate the impact of airborne dioxin exposure on breast cancer risk within the E3N cohort, encompassing 5222 cases identified during the 1990–2011 follow-up and 5222 matched controls. Airborne dioxin exposure was assessed using a Geographic Information System-based metric considering residential proximity to dioxin emitting sources, their technical characteristics, exposure duration and wind direction. Additional analyses were performed using dioxin concentrations estimated by a chemistry transport model, CHIMERE. The results suggest a slightly increased risk between cumulative dioxin exposure at the residential address and overall breast cancer risk (adjusted odds ratio (OR) = 1.03, 95% confidence interval (CI): 0.99–1.07, for a one standard deviation (SD) increment among controls (14.47 log-μg-TEQ/m2). The associations remained consistent for sources within 3, 5, and 10 km, and when restricting exposure to dioxin emissions from household waste incinerators. Similar OR estimates (OR = 1.02, 95% CI: 0.97–1.07, for a one SD increment) were obtained using the CHIMERE model. The findings of this study suggest the possibility of an increased risk of breast cancer associated with long-term residential exposure to dioxins and emphasize the importance of efforts to mitigate air pollution exposure.
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来源期刊
CiteScore
11.50
自引率
5.00%
发文量
151
审稿时长
22 days
期刊介绍: The International Journal of Hygiene and Environmental Health serves as a multidisciplinary forum for original reports on exposure assessment and the reactions to and consequences of human exposure to the biological, chemical, and physical environment. Research reports, short communications, reviews, scientific comments, technical notes, and editorials will be peer-reviewed before acceptance for publication. Priority will be given to articles on epidemiological aspects of environmental toxicology, health risk assessments, susceptible (sub) populations, sanitation and clean water, human biomonitoring, environmental medicine, and public health aspects of exposure-related outcomes.
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