体育锻炼对 Irisin 和 BDNF 浓度的影响及其与代谢综合征患者的心脏代谢和心理健康的关系：系统综述。

IF 3.9

Experimental gerontology Pub Date : 2024-11-24 DOI:10.1016/j.exger.2024.112640

Wilder Villamil-Parra , Luisa Moscoso-Loaiza

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引用次数: 0

摘要

慢性非传染性疾病（NCDs），包括心血管疾病、癌症、慢性呼吸道疾病和糖尿病，是导致全球死亡的主要原因，占每年死亡人数的 71%。以高血压、肥胖、胰岛素抵抗和血脂异常为特征的代谢综合征（MS）是非传染性疾病的重要风险因素。缺乏体育锻炼会加重这些症状，导致心血管和心理健康状况不佳：分析体育锻炼对鸢尾素和脑源性神经营养因子（BDNF）浓度的影响及其与多发性硬化症患者心血管代谢和心理健康的关系：根据PRISMA指南，对2023年8月至2024年6月期间发表在ScienceDirect、PubMed和SciELO上的文章进行了系统综述。纳入标准包括观察性研究、临床试验和方法学质量较高的综述。综述的重点是鸢尾素、BDNF、体育锻炼和多发性硬化症：结果：共发现了 584 篇文章，其中 43 篇被选中进行详细分析。综述强调，体育锻炼会显著影响鸢尾素和 BDNF 的水平，进而影响新陈代谢和心理健康。鸢尾素是一种在运动过程中分泌的肌动素，可促进白色脂肪组织向棕色脂肪组织转化，从而增强能量消耗和新陈代谢健康。鸢尾素水平的升高与认知功能和心理健康的改善有关。BDNF是一种神经营养素，有助于神经元生长和认知功能。运动诱导的 BDNF 水平升高与神经可塑性增强、焦虑减少和情绪改善有关：了解 Irisin 和 BDNF 在体育锻炼中的作用为制定管理和预防多发性硬化症及其相关心理健康问题的策略提供了宝贵的见解。要阐明其中的分子机制，还需要进一步的研究。

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Effects of physical exercise on Irisin and BDNF concentrations, and their relationship with cardiometabolic and mental health of individuals with Metabolic Syndrome: A Systematic Review

Chronic Non-Communicable Diseases (NCDs), including cardiovascular diseases, cancer, chronic respiratory diseases, and diabetes, are the leading global causes of mortality, accounting for 71 % of deaths annually. Metabolic Syndrome (MS), characterized by hypertension, obesity, insulin resistance, and dyslipidemia, is a significant risk factor for NCDs. Physical inactivity exacerbates these conditions, contributing to poor cardiovascular and mental health outcomes.

Objective

To analyze the effects of physical exercise on Irisin and Brain-Derived Neurotrophic Factor (BDNF) concentrations and their relationship with cardiometabolic and mental health of individuals with MS.

Methods

A systematic review was conducted of articles published between August 2023 and June 2024 in ScienceDirect, PubMed, and SciELO, following PRISMA guidelines. Inclusion criteria encompassed observational studies, clinical trials, and reviews with high methodological quality. The review focused on Irisin, BDNF, physical exercise, and MS.

Results

A total of 584 articles were identified, with 43 selected for detailed analysis. The review highlights that physical exercise significantly impacts Irisin and BDNF levels, which in turn influence metabolic and mental health. Irisin, a myokine secreted during exercise, promotes the conversion of white adipose tissue to brown adipose tissue, enhancing energy expenditure and metabolic health. Elevated Irisin levels are associated with improved cognitive function and mental well-being. BDNF, a neurotrophin, supports neuronal growth and cognitive function. Exercise-induced increases in BDNF levels are linked to enhanced neuroplasticity, reduced anxiety, and improved mood.

Conclusion

Understanding the role of Irisin and BDNF in response to physical exercise offers valuable insights for developing strategies to manage and prevent MS and its related mental health issues. Further research is needed to elucidate the molecular mechanisms involved.

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来源期刊

Experimental gerontology Ageing, Biochemistry, Geriatrics and Gerontology

CiteScore

6.70

自引率

0.00%

发文量

审稿时长

66 days