PD-L1 表达和 CD8 + TIL 水平在确定晚期卵巢癌新辅助化疗反应中的预测作用。

IF 3.8 3区医学 Q1 REPRODUCTIVE BIOLOGY

Journal of Ovarian Research Pub Date : 2024-11-23 DOI:10.1186/s13048-024-01533-x

T Aliyeva, B Y Aktas, F Gundogdu, E Chalabiyev, Z Arik, A Usubutun

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The post-NACT tissue samples taken during interval debulking surgery (IDS) were used to evaluate the chemotherapy response score (CRS).Results: Among all the patients, CRS 1 (no response) was found in 8 patients, CRS 2 (partial response) in 28 patients, and CRS 3 (complete response) in 9 patients. A total of 20 (44.4%) patients had high intratumoral CD8 + TILs (iCD8 + TILs) levels, and 35 (77.8%) patients had high expression stromal CD8 + TILs (sCD8 + TILs). No statistically significant relationship was found between high and low expression of i/s CD8 + TILs levels with PFS and CRS. The study found that 33 (73.3%) patients had high levels of stromal PD-L1 (sPD-L1) expression and 28 (62.2%) patients had high levels of intratumoral PD-L1 (iPD-L1) expression. In the iPD-L1 group, patients with low expression had a PFS of 28 months, whereas those with high expression had a PFS of 17 months (p = 0.028). 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引用次数: 0

摘要

目的分析新辅助化疗（NACT）前活检样本中的PD-L1表达和CD8 +肿瘤浸润淋巴细胞（TIL）水平如何预测晚期高级别浆液性卵巢癌（HGSC）的化疗反应评分和生存期：我们回顾性分析了2010年至2018年期间接受过至少三个周期NACT治疗的45例晚期上皮性卵巢癌患者。通过免疫组化染色评估了患者确诊前NACT肿瘤样本中的PD-L1表达和CD8 + TIL水平。在间期去势手术（IDS）中采集的NACT后组织样本用于评估化疗反应评分（CRS）：结果：在所有患者中，8 名患者的 CRS 为 1（无反应），28 名患者的 CRS 为 2（部分反应），9 名患者的 CRS 为 3（完全反应）。共有 20 例（44.4%）患者的瘤内 CD8 + TILs（iCD8 + TILs）水平较高，35 例（77.8%）患者的基质 CD8 + TILs（sCD8 + TILs）表达较高。i/s CD8 + TILs水平的高低与PFS和CRS之间没有统计学意义上的关系。研究发现，33 例（73.3%）患者的基质 PD-L1 （sPD-L1）表达水平较高，28 例（62.2%）患者的瘤内 PD-L1 （iPD-L1）表达水平较高。在 iPD-L1 组中，低表达患者的 PFS 为 28 个月，而高表达患者的 PFS 为 17 个月（p = 0.028）。在 iPD-L1 高表达的患者中，23 例（82.1%）患者出现了 CRS2，4 例（14.3%）出现了 CRS3，只有 1 例（3.6%）出现了 CRS1（p 结论：iPD-L1 高表达患者的 PFS 为 28 个月，而 iPD-L1 高表达患者的 PFS 为 17 个月（p = 0.028）：我们发现，卵巢癌诊断性活检中的 iPD-L1 表达水平可预测间期剥离手术的化疗反应评分。

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The predictive role of PD-L1 expression and CD8 + TIL levels in determining the neoadjuvant chemotherapy response in advanced ovarian cancer.

Objective: To analyze how the PD-L1 expression and CD8 + tumor infiltrating lymphocyte (TIL) levels in biopsy samples before neoadjuvant chemotherapy (NACT) can predict chemotherapy response score and survival for advanced high-grade serous ovarian cancer (HGSC).

Methods: We retrospectively analyzed 45 patients with advanced epithelial ovarian cancer between 2010 and 2018, who had received at least three cycles of NACT. PD-L1 expression and CD8 + TIL levels were evaluated by immunohistochemical staining in the pre-NAC tumor samples from which the patients had been diagnosed. The post-NACT tissue samples taken during interval debulking surgery (IDS) were used to evaluate the chemotherapy response score (CRS).

Results: Among all the patients, CRS 1 (no response) was found in 8 patients, CRS 2 (partial response) in 28 patients, and CRS 3 (complete response) in 9 patients. A total of 20 (44.4%) patients had high intratumoral CD8 + TILs (iCD8 + TILs) levels, and 35 (77.8%) patients had high expression stromal CD8 + TILs (sCD8 + TILs). No statistically significant relationship was found between high and low expression of i/s CD8 + TILs levels with PFS and CRS. The study found that 33 (73.3%) patients had high levels of stromal PD-L1 (sPD-L1) expression and 28 (62.2%) patients had high levels of intratumoral PD-L1 (iPD-L1) expression. In the iPD-L1 group, patients with low expression had a PFS of 28 months, whereas those with high expression had a PFS of 17 months (p = 0.028). Among the patients with high iPD-L1 expression, 23 (82.1%) patients showed CRS2, 4 (14.3%) showed CRS3, and only 1 (3.6%) showed CRS1 (p < 0.001). However, high or low expression sPD-L1 did not significantly affect PFS and CRS (p = 0.928 and p = 0.305; respectively).

Conclusions: We found that iPD-L1 expression levels in diagnostic biopsy in ovarian cancer can predict the chemotherapy response score in interval debulking surgery.

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来源期刊

Journal of Ovarian Research REPRODUCTIVE BIOLOGY-

CiteScore

6.20

自引率

2.50%

发文量

125

审稿时长

>12 weeks

期刊介绍： Journal of Ovarian Research is an open access, peer reviewed, online journal that aims to provide a forum for high-quality basic and clinical research on ovarian function, abnormalities, and cancer. The journal focuses on research that provides new insights into ovarian functions as well as prevention and treatment of diseases afflicting the organ. Topical areas include, but are not restricted to: Ovary development, hormone secretion and regulation Follicle growth and ovulation Infertility and Polycystic ovarian syndrome Regulation of pituitary and other biological functions by ovarian hormones Ovarian cancer, its prevention, diagnosis and treatment Drug development and screening Role of stem cells in ovary development and function.