对接受过夜家庭肠外营养输注的短肠综合征成人进行连续葡萄糖监测。

IF 3.6 3区 医学 Q2 NUTRITION & DIETETICS
Priyasahi Saravana, Meghan Lau, Hassan S Dashti
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引用次数: 0

摘要

背景/目的:使用家庭肠外营养(HPN)的患者容易出现血糖异常。该研究旨在利用连续血糖监测仪(CGM)描述使用 HPN 的患者的 24 小时血糖曲线,并确定影响血糖的因素:使用 Freestyle Libre Pro CGM 评估了 20 名患有短肠综合征 (SBS) 但未患糖尿病的成人的血糖概况。测量指标包括 24 小时平均血糖、变异系数 (%)、在范围内的时间百分比(TIR 70-140 mg/dL)等。HPN 参数和生活方式行为通过自我报告和有效调查获得。线性混合效应模型用于检验血糖指标与年龄、性别和体重指数之间的关系。结果以 P 为显著性:参与者(77% 为女性,年龄 = 52 岁,体重指数 = 21.4 kg/m²,95% 为白人)24 小时血糖平均值和 CV 值分别为 94.69 (8.96) mg/dL 和 20.27%,平均 TIR 值为 87.73%。在非每日依赖 HPN 的患者中,接受 HPN 治疗当天的平均血糖和 TIR 均较高。减少 HPN 与 CV 降低-6.882%(95% 置信区间 = -12.436,-1.329)相关,每克 HPN 葡萄糖含量越高,CV 升高 0.039%(95% 置信区间 = 0.008,0.07)。吸烟、抑郁症状较多和失眠严重程度较高与血糖水平和变异性有关:代谢稳定的 HPN 成人消费者的 24 小时血糖测量值与健康成人相当,但明显低于范围的时间更长。血糖曲线受 HPN 参数(如减量和葡萄糖)和行为(包括吸烟、抑郁症状和失眠)的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Continuous glucose monitoring in adults with short bowel syndrome receiving overnight infusions of home parenteral nutrition.

Background/objectives: Consumers of home parenteral nutrition (HPN) are susceptible to dysglycemia. The aim was to characterize 24-h glucose profiles of HPN consumers using continuous glucose monitors (CGM) and to identify factors that influence glucose.

Subjects/methods: Glucose profiles of 20 adults with short bowel syndrome (SBS) without diabetes were assessed using the Freestyle Libre Pro CGM. Measures included mean 24-h glucose, coefficient of variation (%), % time in range (TIR 70-140 mg/dL), among others. HPN parameters and lifestyle behaviors were obtained from self-reports and validated surveys. Linear mixed-effects models were used to test associations with glycemic measures adjusted for age, sex, and BMI. Significance was considered at P < 0.05.

Results: Participants (77% female, age = 52 years, BMI = 21.4 kg/m², 95% white) had a 24-h mean and CV for glucose of 94.69 (8.96) mg/dL and 20.27%, respectively, and a mean TIR of 87.73%. Among non-daily HPN-dependent patients, the mean glucose and TIR were higher on days receiving HPN. Tapering HPN was associated with -6.882 (95% confidence interval = -12.436, -1.329) % lower CV, and higher HPN dextrose content per gram was associated with 0.039 (95% confidence interval = 0.008, 0.07) % higher CV. Smoking, more depressive symptoms, and higher insomnia severity showed associations with glucose levels and variability.

Conclusions: Metabolically stable HPN adult consumers have 24-h glucose measures comparable to healthy adults yet are notable for more time spent below range. The glucose profiles are influenced by HPN parameters such as tapering and dextrose and behaviors including smoking, depressive symptoms, and insomnia.

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来源期刊
CiteScore
10.60
自引率
2.10%
发文量
189
审稿时长
3-6 weeks
期刊介绍: The European Journal of Clinical Nutrition (EJCN) is an international, peer-reviewed journal covering all aspects of human and clinical nutrition. The journal welcomes original research, reviews, case reports and brief communications based on clinical, metabolic and epidemiological studies that describe methodologies, mechanisms, associations and benefits of nutritional interventions for clinical disease and health promotion. Topics of interest include but are not limited to: Nutrition and Health (including climate and ecological aspects) Metabolism & Metabolomics Genomics and personalized strategies in nutrition Nutrition during the early life cycle Health issues and nutrition in the elderly Phenotyping in clinical nutrition Nutrition in acute and chronic diseases The double burden of ''malnutrition'': Under-nutrition and Obesity Prevention of Non Communicable Diseases (NCD)
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