体外低脉冲激光照射对人血小板形态功能特性的影响

IF 0.9 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-23 DOI:10.1007/s10517-024-06297-4

M S Makarov, N V Borovkova, M V Storozheva, I N Ponomarev

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引用次数: 0

摘要

我们研究了体外暴露于不同波长低脉冲激光辐射（LPLR）的人体血小板的形态功能特征。富血小板血浆（PRP）的照射波长分别为 635、488 和 355 纳米。波长为 λ=635 nm、功率为 1 W 的 LPLR 在 10 分钟后会导致许多血小板脱颗粒，形成小的血小板聚集体，并加速血小板在玻璃上的粘附。波长为 λ=635 nm、功率为 2 mW 的 LPLR 和波长为 λ=488 nm 的 LPLR 没有引起血小板形态功能状态的显著变化。波长为 λ=355 nm 的 LPLR 会导致血小板大量变形，形态功能状态急剧下降，但不会激活血小板。

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Effect of In Vitro Low-Impulse Laser Irradiation on Morphofunctional Properties of Human Platelets.

We studied morphofunctional features of human platelets exposed in vitro to low-pulse laser radiation (LPLR) with different wavelengths. Platelet-rich plasma (PRP) was irradiated at wavelengths of 635, 488, and 355 nm. LPLR with λ=635 nm and 1 W power after 10 min caused degranulation of many platelets, formation of small platelet conglomerates, and accelerated platelet adhesion on glass. LPLR with λ=635 nm and 2 mW and LPLR with λ=488 nm did not cause significant changes in the morphofunctional platelet status. LPLR with λ=355 nm induced massive platelets' deformation, sharp decrease in their morphofunctional status without activation.

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.