良性胆囊疾病后患泛胰腺癌的风险:一项瑞典人群队列研究。

IF 7.6 1区 医学 Q1 ONCOLOGY
Cecilia Radkiewicz , Jonas F. Ludvigsson , Ernesto Sparrelid , Louise Emilsson
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引用次数: 0

摘要

目的:这项基于登记的全国性队列研究旨在概述良性胆囊疾病(GBD)后的胰腺癌风险。对解剖学上相邻的癌症进行调查,以解决偶然发现的问题:我们纳入了 1992-2016 年间所有经组织学证实患有 GBD(胆囊炎和/或胆囊切除术)的 20-79 岁瑞典人以及五个匹配的非暴露人群比较者。随访从 GBD 后一个月开始,采用泊松回归和 Cox 回归分别估算了 GBD 后 15 年的发病率 (IR) 和危险比 (HR) 以及 95 % 置信区间 (CI)。完全调整模型包括性别、年龄、年份、教育程度、2 型糖尿病、肥胖、吸烟和酗酒相关疾病。根据随访情况进行分层分析,并采用灵活的参数模型来评估时变效应。交互模型用于确定高危患者群体:结果:15年间,在130907名暴露于GBD的患者和571618名未暴露于GBD的患者中,分别发现了680例和1890例胰腺癌。胰腺癌的超额风险主要出现在最初的 2 年内;IR:84 [95 % CI 73,95] 对 31 [95 % CI 27,34]/100000人年,对应 HR 为 2.74 [95 % CI 2.31,3.25]。十二指肠癌的情况也是如此,而原发性肝癌的风险在整个随访期间都有所升高。肝外胆道癌风险从最初的升高转为随时间推移而降低。年轻(20-49 岁)人群的 2 年胰腺癌风险增加,HR 为 7.64 [95 % CI 3.73,15.65]:我们的研究结果呼吁对胆囊炎后最初几年的临床随访进行更多研究,以发现早期胰腺癌。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Panacreatic cancer risk after benign gallbladder disease: A Swedish population-based cohort study

Aim

The purpose of this nationwide registry-based cohort study was to outline pancreatic cancer risk after benign gallbladder disease (GBD). Anatomically adjacent cancers were investigated to address incidental findings.

Methods

We included all Swedes aged 20–79 years with histologically confirmed GBD (cholecystitis and/or cholecystectomy) in 1992–2016 and five matched non-exposed population comparators. Follow-up started one month after GBD and incidence rates (IR) and hazard ratios (HR) with 95 % confidence intervals (CI) up to 15 years after GBD were estimated using Poisson and Cox regression, respectively. Fully adjusted models included sex, age, year, education, type 2 diabetes, obesity, smoking-, and alcohol-related disorders. Analyses were stratified by follow-up and flexible parametric models applied to assess time-varying effects. Interaction models were used to identify patient groups at risk.

Results

680 and 1890 incident pancreatic cancers were detected over 15 years in 130907 GBD exposed and 571618 non-exposed, respectively. An excess pancreatic cancer risk was mainly seen within the first 2 years; IR: 84 [95 % CI 73,95] versus 31 [95 % CI 27,34] per 100000 person-years corresponding to an HR of 2.74 [95 % CI 2.31,3.25]. The same pattern was noted for duodenal cancer while primary liver cancer risk was elevated across follow-up. An initial extrahepatic biliary cancer risk elevation shifted to a reduction over time. The 2-year pancreatic cancer risk was augmented in younger (age 20–49) individuals, HR 7.64 [95 % CI 3.73,15.65].

Conclusion

Our findings urge more studies on the clinical follow-up the first years after cholecystitis to detect early pancreatic cancer.
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来源期刊
European Journal of Cancer
European Journal of Cancer 医学-肿瘤学
CiteScore
11.50
自引率
4.80%
发文量
953
审稿时长
23 days
期刊介绍: The European Journal of Cancer (EJC) serves as a comprehensive platform integrating preclinical, digital, translational, and clinical research across the spectrum of cancer. From epidemiology, carcinogenesis, and biology to groundbreaking innovations in cancer treatment and patient care, the journal covers a wide array of topics. We publish original research, reviews, previews, editorial comments, and correspondence, fostering dialogue and advancement in the fight against cancer. Join us in our mission to drive progress and improve outcomes in cancer research and patient care.
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